Haoyu Zhang (@andrewhaoyu) 's Twitter Profile
Haoyu Zhang

@andrewhaoyu

Investigator @NCIEpiTraining, Statistics, Genetics and Genomics, Data Science. Views are all mine

ID: 754114452430073856

linkhttps://andrewhaoyu.github.io/ calendar_today16-07-2016 00:44:31

370 Tweet

555 Followers

271 Following

Luke O'Connor (@luke0connor) 's Twitter Profile Photo

Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC Led by the fantastic Hui Li, and co-supervised by Xihong Lin #ASHG24 poster 4089F medrxiv.org/content/10.110…

Haoyu Zhang (@andrewhaoyu) 's Twitter Profile Photo

Interested in PRS methods using continuous ancestries information? Check out our recent preprint: biorxiv.org/content/10.110…. The work will also be presented as a ASHG poster at Board 4128T Nov 7th 2:30-4:30 by an excellent PhD student Tony! Feel free to stop by!!

Pradeep Natarajan (@pnatarajanmd) 's Twitter Profile Photo

Current polygenic risk scores require binning of ancestry groups but we know ancestry is a continuum. Our study led by Yunfeng Ruan🌻 #StandWithUkraine🌻 introduces DiscoDivas, a new generalizable PRS framework across the ancestry spectrum medrxiv.org/content/10.110… medRxiv PRIMED Consortium

Current polygenic risk scores require binning of ancestry groups but we know ancestry is a continuum. Our study led by <a href="/Yunfeng_Ruan/">Yunfeng Ruan🌻 #StandWithUkraine🌻</a> introduces DiscoDivas, a new generalizable PRS framework across the ancestry spectrum medrxiv.org/content/10.110… <a href="/medrxivpreprint/">medRxiv</a> <a href="/PRSdiversity/">PRIMED Consortium</a>
Yunfeng Ruan🌻 #StandWithUkraine🌻 (@yunfeng_ruan) 's Twitter Profile Photo

Thank you Pradeep for your support and advice for this project🙏😃 We’re thrilled to introduce DiscoDivas, a new method designed to generate Polygenic Risk Scores (PRS) for diverse espcially admixed populations 1/

Qiongshi Lu (@q_statgen) 's Twitter Profile Photo

Our new PRS paper is out! We introduce a method to create regularized ensemble PRS on GWAS sumstats. Individual-level data is no longer needed for sophisticated ensemble learning Zijie Zhao Stephen Dorn Paper📰:biorxiv.org/content/10.110… Software🧑‍💻:github.com/qlu-lab/PUMAS

Our new PRS paper is out! We introduce a method to create regularized ensemble PRS on GWAS sumstats. Individual-level data is no longer needed for sophisticated ensemble learning <a href="/ZijieZhao1996/">Zijie Zhao</a> <a href="/stphn_drn/">Stephen Dorn</a> 
Paper📰:biorxiv.org/content/10.110…
Software🧑‍💻:github.com/qlu-lab/PUMAS
Zhonghua Liu (@zhliu13) 's Twitter Profile Photo

Excited to share our latest work in Cell Genomics! Using a novel MR method integrated with AlphaFold3, we identify Alzheimer’s-associated proteins with 3D structural changes. cell.com/cell-genomics/… Andrea Baccarelli Gary W Miller ColumbiaPublicHealth Cell Genomics

Julie Alexia (@alexiadiasf) 's Twitter Profile Photo

Excited to share our new manuscript on evaluating multi-ancestry GWAS methods using large-scale simulations & real data from UK Biobank (N≈324K) & All of Us (N≈207K)! My first thesis paper under the guidance of Pete Kraft & Haoyu Zhang. Available at: medrxiv.org/content/10.110…

Excited to share our new manuscript on evaluating multi-ancestry GWAS methods using large-scale simulations &amp; real data from UK Biobank (N≈324K) &amp; All of Us (N≈207K)! My first thesis paper under the guidance of <a href="/GENES_PK/">Pete Kraft</a> &amp; <a href="/AndrewHaoyu/">Haoyu Zhang</a>. Available at: medrxiv.org/content/10.110…
Pradeep Natarajan (@pnatarajanmd) 's Twitter Profile Photo

Very excited to share our preprint led by Michael Levin Satoshi Koyama Jakob Woerner & with Scott Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! medrxiv.org/content/10.110… medRxiv [1/3]

Very excited to share our preprint led by <a href="/MGLevin/">Michael Levin</a> <a href="/skoyamamd/">Satoshi Koyama</a> <a href="/jakob_woerner/">Jakob Woerner</a> &amp; with <a href="/damrauer/">Scott Damrauer</a> assessing genome-wide pleiotropy of &gt;1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! 
medrxiv.org/content/10.110… <a href="/medrxivpreprint/">medRxiv</a> 

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Pradeep Natarajan (@pnatarajanmd) 's Twitter Profile Photo

Delighted to collaborate with J. Hu and Hongyu Zhao to show that genetic mechanisms leading to a high CAD polygenic risk score are heterogeneous, which may have implications for prevention journals.plos.org/ploscompbiol/a… PLOS Comp Biol

Delighted to collaborate with J. Hu and <a href="/HongyuZhao2/">Hongyu Zhao</a> to show that genetic mechanisms leading to a high CAD polygenic risk score are heterogeneous, which may have implications for prevention journals.plos.org/ploscompbiol/a… <a href="/PLOSCompBiol/">PLOS Comp Biol</a>