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I want to tell you a story about a recent discovery that we made in the lab, because we often argue here whether it’s the data or the hypothesis that comes first. In the case of this discovery, it was definitely the data that showed us something that we completely didn't expect.

A TRIP to understand gene regulation bit.ly/3ups0FH #ResearchHighlight by Mike Attwaters

H-NS is a bacterial transposon capture protein !!! biorxiv.org/content/10.110…

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… @Gustavo_SFranca

Direct single-cell observation of a key Escherichia coli cell-cycle oscillator | Science Advances Our paper on the coupling of the oscillations in DnaA activity and expression with cell size is now published ! A great ongoing collaboration with Statistical Physics of Cells and Genomes.

My PhD work on harnessing the brain parasite Toxoplasma gondii for protein delivery to the brain is out in Nature Microbiology ! nature.com/articles/s4156…

As someone who’s been mentoring future PIs for a while, I often get asked how I choose post-docs for my lab and if I have a crystal ball for predicting their success. Well, here is the scoop: I don’t! But here are some things I look for: (1/8)

I feel compelled to share my take. TL;DR: (1) the first iteration of anything cannot be perfect, (2) a one-size-fits-all path can be a minefield, (3) let's value diverse voices, (4) let’s prioritize rigorous tools even if, on the surface, it looks like they achieve less. [1/19]

🚨𝐇𝐞 𝐋𝐚𝐛 job opportunity UC San Francisco 🚨: I'm hiring TWO postdocs - an experimentalist and a computational biologist. Join us to use cutting-edge single-cell and spatial technologies to unravel the mysteries of human tissues. opportunities.ucsf.edu/content/open-p…

Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank

1. This summer I've been thinking a lot about "cognitive load" which is term that has multiple definitions but for me means something like "the amount of processing, analysing, thinking, & deciding I can do in a day before my brain stops working" here's a short thread about that

🔥Here is an amazing opportunity to do exciting science with a wonderful new assistant professor!

Congratulations to David´s team! 👏🥂We all in the trypanosoma field have been saying "RNA is regulated by UTRs" without much actual evidence. Anna performed a massive screen showing the effect of each individual 3´UTR, revealing a positive effect of A-rich regions.🤩

Universities are not just businesses, but an investment in future generations go.nature.com/4gBwfRI