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While adult mammals are unable to grow new nephrons, cartilaginous fish kidneys display nephrogenesis throughout life. This first molecular analysis of nephron progenitor cells (NPCs) in a chondrichthyan species indicates that translation rate increases in NPCs as they

The aim of this study was to examine whether senescence biomarkers are associated with frailty and physical function trajectories in patients undergoing #kidneytransplant. #MedEd Carrie Schinstock Hani Wadei Andrew Rule Nathan LeBrasseur Journal of Clinical and Translational Research bit.ly/4iafY6X

The Many Moods of Machine Learning If you feel overwhelmed by the jargon of machine learning and wonder how it all ties together, you aren’t alone. There's training vs test data, supervised vs unsupervised vs self-supervised learning, regression vs classification, linear vs

Glomerular and Nephron Size and Kidney Disease Outcomes: A Comparison of Manual Versus Deep Learning Methods in Kidney Pathology Andrew Rule Kidney Medicine pubmed.ncbi.nlm.nih.gov/39807248/

This study aimed to assess whether #kidneystone burden and risk factors at the time of #kidneydonor evaluation were associated with a symptomatic stone event post-donor evaluation. Andrew Rule Hani Wadei Carrie Jadlowiec Matthew D'Costa Mira Keddis,MD,FACP bit.ly/411D6y2

If you donate your kidney, what about the kidney structure on imaging or microscopy best predicts how well that kidney will function in the recipient? It’s the number of medullary pyramids! sciencedirect.com/science/articl…

The number of nephrons your kidneys start with is set at birth… or is it? kireports.org/article/S2468-…

Kidney donation is a gift of life. How can we improve the experience for the donor after donation. A summary of the literature: journals.lww.com/transplantjour…

In Press! "Fewer medullary pyramids in the living kidney donor associate with graft failure in the recipient" by Riad et al. buff.ly/4iaWFcY Andrew Rule #kidneytransplantation

Can eGFRcr-cys be used to better dose cefepime in order to avoid both treatment failure and toxicity? The answer is yes, but you also need to use a different dosing nomogram than used for eGFRcr. Dosing algorithms need to be optimized to the eGFR used! journals.lww.com/ccmjournal/abs…

On #RareDiseaseDay, our NIDDK P20 Center Mayo Clinic Urology Mayo Clinic Nephrology is raising awareness with the Oxalosis and Hyperoxaluria Foundation Oxalosis & Hyperoxaluria Foundation to support the #hyperoxaluria community and every patient living with a rare condition. We're committed to research for a cure!

#Nephron #Number in #Pediatric Patients doi.org/10.1016/j.ekir… Original Article: doi.org/10.1016/j.ekir… #KIRCommentary

The prevalence of hypertension has been well studied, but what about incidence? We recently completed the most thorough study of the incidence of hypertension across 6 decades. Something happened in the 1990s that markedly increased hypertension! mayoclinicproceedings.org/article/S0025-…

📣NEW EPISODE: A physician, dietitian, pharmacist, and patient walk into a podcast...and what follows? A powerhouse conversation on kidney stone risks, recurrence, and prevention. 🎧 Just in time for holiday travel, don’t miss this ride of the Kidney Commute! #KidneyStones

sciencedirect.com/science/articl… A multilayer AI model to precisely characterize chronic changes on kidney histology.

A Multiomics Study of Circulating Proteins and Kidney Stone Risk Andrew Rule John Lieske MD #MayoClinicKidney journals.lww.com/jasn/abstract/…

kireports.org/article/S2468-… Podocyte number per glomerulus predicts progressive CKD independent of clinical characteristics (GFR and proteinuria) or other microstructural pathology (glomerular size or nephrosclerosis)!

Mayo Clinic will light buildings across its campuses in red, white and blue this evening to celebrate Independence Day. Wishing everyone a joyful and safe Fourth of July!