Showing that germline mutations of MAD1L1 as the cause of a new aneuploidy syndrome with systemic inflammation and high tumor susceptibility. Kevin Monahan Terri McVeigh LynchSyndrome_Polyposis@StMarks Andy Latchford Heather Hampel Colorectal Cancer Canada Asociación Española de Genética Humana (AEGH) CNIO Stop Cancer Laura Valle

“A short course of neoadjuvant chemotherapy represents a reasonable treatment option for patients with clinical stage T3+ operable, MMR-proficient colon cancer” ascopubs.org/doi/full/10.12…

Fascinating GR by Dr Judith Johnson St Mark's Hospital on Burnout. It’s under-reported and costly. It can be addressed if organizations offer more resources & support, build cognitive flexibility, enhance self-esteem & #resilience

📢The wait is finally over‼️ ➡️ We're pleased to release the FULL interview w/ #DIRECt members Drs Swati G. Patel, MD MS Giulia Martina Cavestro MD PhD Mannucci & Marta Puzzono, who are zooming in on the #eoCRC initiative. Watch🔗tinyurl.com/mwckuf2b #ColorectalCancerAwarenessMonth #HereditaryGICancer Mev Dominguez Valentin

Precision oncology for a chemotherapy in CRC??🤯🤯🤯 We did it in a huge collaborative effort! 🧵 below 👇👇👇 Or read how we addressed this longstanding quest in today’s Nature Medicine : nature.com/articles/s4159… 1/14

1/We're thrilled to announce that the #eoCRC toolkit is now available❗️ 👉🔗tinyurl.com/yc3p4wzu Anything missing❓ Let us know. 🧵 #HereditaryGICancer #ColorectalCancerAwarenessMonth

3/A key resource are the #eoCRC guidelines from #DIRECt, an int'l group of experts w/ lead author Giulia Martina Cavestro MD PhD & #CGAIGC, EHTGtweets InSiGHT & AIFET 👉🔗tinyurl.com/mwckuf2b #HereditaryGICancer #ColorectalCancerAwarenessMonth

Great away day afternoon ⁦Royal College of Physicians⁩ discussing where we are now and where we want to be. Lots of discussion and 💡….now to put it all into practice ⁦LynchSyndrome_Polyposis@StMarks⁩ ⁦Polyposis Registry 🧬⁩ ⁦St Mark's Hospital Foundation⁩ ⁦

The personal & societal loss of #eoCRC is huge. Often there is a #familial aspect We encourage the multidisciplinary HC team to use evidence-based guidelines developed by #DIRECt when treating individuals with #eoCRC 🔗tinyurl.com/49kz38a4 #MyCRCMoonshot #HereditaryGICancer

#CGAIGC will continue its collaborative efforts w/ the global multidisciplinary #HereditaryGICommunity who brings a unique & much needed perspective to #eoCRC We urge #HCPs working w/ #eoCRC #patients to use #DIRECt guidelines in their daily #clinicalpractice #MyCRCMoonshot

Research in the field of hereditary tumor diseases often fails due to small data sets and selection bias. 🤔 ➡️ sharing data is hampered by legal and regulatory obstacles ➡️ Swarm Learning is a possible solution Take a look at the SHARE-initiative.org

BMPR2 as a novel predisposition gene for hereditary colorectal polypos... sciencedirect.com/science/articl… by Sergi Castellví Bel 🇪🇺🏳️‍🌈 Laia Bonjoch

Biology of Pre-cancers and Opportunities for Cancer Interception – lesson from colorectal cancer susceptibility syndromes. aacrjournals.org/cancerpreventi… Andy Latchford Ottilie Swinyard LynchSyndrome_Polyposis@StMarks

Pleased to announce the publication of the Position statement of the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) on APC I1307K & cancer risk pubmed.ncbi.nlm.nih.gov/37076288/

Recommendations based on published evidence (data re-analysis) and thorough discussion of the results. By: Andy Latchford, @bhealdleach, Dr Ian Frayling 🇺🇦 #LongCovid, Pilar Mur, L. Katz, V. Moreno, G. Capellá & Laura Valle.

📣 Microsatellite instability in noncolorectal and nonendometrial malignancies in patients with Lynch syndrome academic.oup.com/jnci/advance-a… #cancergenomics #radboudumc #lynchsyndrome

📣: Hot off the press: Now out in the #LynchSyndrome community, we expand our knowledge from the 'Naproxen Trial' by discovering that daily naproxen maintains proliferation of CD8 T cells in colorectal mucosa. #VilarLab Eduardo Vilar MD Anderson Cancer Center

And also next tuesday, in Digestive Disease Week, we will be presenting our work from #SECOC consortium about a possible new risk factor for #EOCRC: Telomere length. IBSAL Fight Colorectal Cancer CGA-IGC Digestive Disease Week American Gastroenterological Association (AGA) Digestive Cancers Europe European Society of Coloproctology my_UEG FightEAOCRC @AbelMartel10

👉🏻 Recognizing the ongoing European FAP consortium aimed at evaluating a new personalized surveillance protocol in FAP at CGA-IGC #CGAIGC23 thieme-connect.com/products/ejour… Arthur Aelvoet,H.Bouchiba, Evelien Dekker Maria Daca Alvarez mariapellise rodrigo jover Andy Latchford Roel Hompes

Laura Thomas presenting the update on MAP duodenal polyposis 👉🏻 24% developed duodenal adenomas 👉🏻 high proportion of HGD in adenomas <10 mm 👉🏻 Spigelman staging appears to be inappropriate for guidance and management 👉🏻 genotype-phenotype association #CGAIGC23 CGA-IGC