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Late to the party, as was published in June, but happy to be part of this work by G.Berecki, S.Petrou and others, in Brain. Not all SCN2A variants causing neonatal-onset DEE are straightforward gain-of-function: a finding with treatment implications. academic.oup.com/brain/advance-…

I had a lovely visit to Institute for Molecular Bioscience and Queensland Brain Institute, UQ this week. Discussed lots of great brain science and got to see superstar Rosemary Cater, PhD new lab! Thanks to Anggono Lab for the invite and hosting me. Dehorter Lab Pranesh Padmanabhan

Nav1.7 and Cholesterol: Our MD simulations & in-vitro patch clamp suggest that Cholesterol depletion increases Nav1.7 current densities and alters fast inactivation: doi.org/10.1016/j.ijbi…. Thank you Vishal Eswaran, Simone Albani and Giulia Rossetti for the fruitful collab!

Congratulations on a cool ion channel biophysics study.

We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.

An ant venom peptide, Ta3a, binds to voltage-gated sodium channels, holds their voltage sensors in the activated (up) configuration to create a bilayer of fixed positive charges and mobile anions. No wonder ant stings are so painful……clever ants!! sciencedirect.com/science/articl…

"Voltage-dependent G-protein Regulation of CaV2.2 (N-type) Channels”: The 1st part of our team's "CaV2 trilogy" was just published in @scienceadvances! 🧵about how a human presynaptic channel consolidates ⚡️electrical, #Gproteins and #calcium signaling science.org/doi/10.1126/sc… 1/9

“If academics generally had other prestige mechanisms they could refer to—such as actually reading the articles more carefully when making tenure decisions—they wouldn’t depend so much on the publishers.” Hi, hi, hi!!! So true! insidehighered.com/news/faculty-i…

So sad to hear that my wonderful PhD supervisor Shin-Ho Chung passed away last week. He made a huge impact on the ion channel community and will be sorely missed. His amazing BD movies will stay forever in my mind. #biophysics #AusBiophysics #ionchannel Biophysical Society

1st individual gene mutation test for predicting risk of sudden cardiac death has been developed by Prof Jamie Vandenberg + Dr Chai Ng. The collaborative research in Circulation will make a huge difference in how high-risk Long QT patients are cared for: smh.com.au/national/what-…

The TMEM132B-GABAA receptor complex controls alcohol actions in the brain: Cell cell.com/cell/fulltext/…

Thank you for the opportunity to contribute to this significant discovery. Congratulations to all the team, particularly Guohao. A fantastic outcome for all involved.

Wisedchaisri et al. describe structural basis for severe #pain caused by mutations in the voltage sensors of sodium channel NaV1.7. hubs.la/Q02RDhN30 📒 In our #Neuroscience collection: hubs.la/Q02RDnDv0 #SfN24

📰Excited to share our latest work just published in Nature Communications Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow nature.com/articles/s4146… 🧵

We all enjoyed this project Ashvriya Thapa, Samuel Robinson. The link to the paper is here: doi.org/10.1016/j.jbc.…

I updated the blog post with a simple function to calculate the membrane voltage sag in Python. I also included an example of using the function within a loop to analyze multiple files. Hope you find it useful! spikesandbursts.wordpress.com/2022/05/13/pat…

Allways a pleasure to read these single channel studies. Congratulations to the authors.

Asynchronous subunit transitions precede acetylcholine receptor activation | bioRxiv biorxiv.org/content/10.110…

Publication alert 📢 Understanding paralogous #epilepsy–associated GABAA receptor variants 🤩 Our findings illustrate how gene family information may facilitate variant interpretation👍 Excellent work by Anthony Kan (Sze Hon), Ali Kusay and Nazanin Azarinejad Mohammadi 👏 pnas.org/doi/10.1073/pn…

Resolving native GABAA receptor structures from the human brain | Nature doi.org/10.1038/s41586…