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This week's new issue of Science Translational Medicine has arrived! fcld.ly/v0fdjvb

Proud and humbled to share our recent paper on Nature Communications!It's such a thrill to see the paper finally out! Huge thanks to my PI Paola Romagnani and to Elena Lazzeri How does the kidney adapt to AKI? #polyploidy #AKI #CKD 👇 nature.com/articles/s4146…

A new study from our group demonstrates that tubular cell polyploidy protects from lethal AKI but promotes consequent CKD. Just published in Nature Communications nature.com/articles/s4146…

You did a great work LetiziaDeChiara finally clarifying that the kidney after an AKI fastly recovers function by polyploidization of tubular cells but these polyploid cells later become senescent driving CKD! Thanks also to fantastic work of Elena Lazzeri

A huge thanks to all the co-authors for their valuable inputs Carolina Conte Maria Lucia Angelotti Laura Lasagni Maria Elena Melica Giulia Antonelli Samuela Landini Anna Julie Peired Alice Molli Marta Donati Marco Allinovi Roberto Semeraro Alberto Magi Hans-Joachim Anders nature.com/articles/s4146…

After kidney injury, polyploidization of tubular epithelial cells is the quickest way to adapt and sustain residual kidney function to assure survival Paola Romagnani Elena Lazzeri nature.com/articles/s4146…

Polyploid tubular epithelial cells become senescent in the long run driving AKI-CKD progression.. however blocking continuos tubular cells polyploidization through YAP1 inhibition or senolytic therapy is able to prevent CKD progression 👇👇👇 nature.com/articles/s4146…

Evolution selected kidney hypertrophy by tubular cell polyploidy as a fast and efficient mechanism to reduce the risk of death after AKI. Knocking out YAP1 in tubular cells blocks polyploidy and kidney hypertrophy= death for AKI nature.com/articles/s4146…

Single Cell-RNAseq on mouse kidneys after AKI and in vitro human cell culture showed that polyploidization of tubular epithelial cells depend on YAP1 activation

Excited to share our last work on JASN_News. Genetic diagnosis of kidney diseases is feasible, cost-saving and extremely important for our patients. Thanks to Paola Romagnani Luigi Cirillo Valentina Raglianti Gianmarco Lugli Viviana Palazzo Samuela Landini LetiziaDeChiara

Using our diagnostic algorithm we changed the initial clinical diagnosis in 1/5 of patients with genetic kidney diseases. Reported in our new study in JASN bit.ly/JASN076

Thanks to Luigi Cirillo work we could establish that early use of whole exome sequencing during the diagnostic process, when applied in the context of our workflow, can even reduce the costs for diagnoses

Now in JASN_News. Finerenone Added to RAS/SGLT2 Blockade for Chronic Kidney Disease in Alport Syndrome. Results of a Randomized Contr… pubmed.ncbi.nlm.nih.gov/37428955/

Our new study is out! By STED microscopy on kidney biopsy and ELISA assays we show 1/3 of pediatric and half of adult patients (more in primary FSGS) have autoantibodies against slit antigens different from nephrin. i.e. anti-slit Abs kidney-international.org/action/showPdf…

Anti-slit antibodies define response to therapy and prognosis much better than histopathological lesion patterns even among patients with steroid-resistant nephrotic syndrome kidney-international.org/action/showPdf…

Look how much more important is to know if a patient is genetic or has anti-slit antibodies than if has MCD or FSGS at kidney biopsy. We have finally come to the era of autoimmune, genetic and adaptive podocytopathies. No more MCD or FSGS used as diagnosis!

Anti-slit diaphragm antibodies on kidney biopsy identify pediatric patients with steroid-resistant nephrotic syndrome responsive to second-line immunosuppressants. doi.org/10.1016/j.kint… Università di Firenze Universitat de Barcelona Universität München #OpenAccess #pediatricnephrology

Now open access Nature Reviews Disease Primers Chronic Kidney Disease All you need to know about CKD and how to halt CKD progression rdcu.be/d71Rj

Our new study reporting anti-slit autoantibodies against podocin and Kirrel1 in a subset of patients with nephrotic syndrome is out in JASN journals.lww.com/jasn/citation/…

Anti-slit diaphragm antibodies in autoimmune podocytopathy: •Anti-nephrin → frequent in kids •Anti-podocin → in kids & adults •Anti-Kirrel1 → more rare •Some patients have multiple autoantibodies. journals.lww.com/jasn/citation/…