Very happy that our paper is now out in Alzheimer’s Research & Therapy where we show that tau-PET and Braak-staging are highly predictive markers of cognitive decline in cognitively normal to individuals with #AlzheimersDisease. Many thanks to Nico Franzmeier and ISD Research alzres.biomedcentral.com/articles/10.11…

1/Happy to share our newest #preprint showing connectivity-mediated tau spreading in 4R tauopathies, combining 2nd gen tau-PET, cell-type-specific post-mortem tau and fMRI doi.org/10.1101/2021.0… Many thanks to MatthiasBrendel, @GunterHoglinger, Michael Ewers! Summary in the thread

Happy to share our newest #preprint: "Polygenic effect on accelerated #TAU pathology accumulation in #Alzheimers disease: Implications for patient selection in clinical trials" #ENDALZ

Our first preprint of 2022: "#Amyloid-associated increases in soluble #tau is a key driver in accumulation of tau aggregates and cognitive decline in early #Alzheimer", bit.ly/3tcIhe7. co-lead by @alexa_pichetb & Nico Franzmeier, w/Oskar Hansson BioFINDER and others.

Interested in visualising 🧠imaging data in R? Here are a few beginner-friendly notebooks you can work through to briefly introduce you to some voxel, ROI, edge & vertex level visualisation tools! github.com/sidchop/neuRo-…

Very happy to share our latest preprint, showing that higher levels of #myelin are associated with higher resistance against #tau pathology in #Alzheimers disease. Many thanks to Michael Ewers Nico Franzmeier BioFINDER and others! tinyurl.com/bdd455xv

Happy to share our new work out in Nature Communications: Tau deposition patterns are associated with functional connectivity in 4R tauopathies, using PET and post-mortem data. Thanks to co-first author MatthiasBrendel, Michael Ewers @GunterHoglinger and many others! rdcu.be/cI029

Join our virtual session on "Myelin changes and associated microglia activation as drivers of Alzheimer’s disease" today at 11.15 am PDT #AAIC2022 . Talks by A. Kohli from Bendlin Lab Dr. Constanze Depp Oskar Harari Oscar Harari and twitterless Mikael Simons @DZNE_en

Very happy to share our new Nature Communications paper, showing that earlier #Alzheimer's onset is associated with stronger tau in globally connected hubs, and that tau in hubs leads to faster connectivity-mediated tau spreading and cognitive decline doi.org/10.1038/s41467… 1/5

Check out our new preprint, showing that earliest Abeta abnormalities are associated with a sTREM2-related microglial response, which may drive p-tau elevations. Many thanks to Nico Franzmeier, MatthiasBrendel and Marc Suárez-Calvet 🧠🧪 🩺🌈 and all other co-authors! medrxiv.org/content/10.110…

Many thanks to Alzforum for highlighting our work, summarizing collaborative studies on tau spreading from @alexa_pichetb, Oskar Hansson, Davina Biel, @LFrontzkowski, Michael Ewers, Anna Rubinski and many others!

neuromaps: structural and functional interpretation of brain maps | nature.com/articles/s4159… GoogleMaps for the brain! By Ross Markello Justine Hansen out now in Nature Methods 🧠🧰⤵️

ADNI4 paper is out! 👇 Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community‐engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4 alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Very happy to share our new work in Nature Communications, showing that amyloid-related spreading of fibrillar tau is driven by soluble p-tau in #Alzheimer's disease. Many thanks to co-first author @alexa_pichetb, RikOssenkoppele, Oskar Hansson and many others! doi.org/10.1038/s41467…

Happy to share our new work where we show that combining tau-PET with fMRI-derived maps of cognitive domains improves the prediction of cognitive decline and the sensitivity to detect treatment effects. Thanks to Nico Franzmeier, MatthiasBrendel and all co-authors! rdcu.be/cZcf9

Very happy to share our new work by Anna Steward, out in Alzheimer's & Dementia Journals showing that higher brain network segregation is associated with attenuated tau spreading in #Alzheimer's. This suggests that more segregated brain networks may provide #resilience against tau spreading

Finally online in its formatted and definitely more reader friendly version: Anna Dewenter used Fixel based analyses applied to diffusion MRI data to disentangle effects of Alzheimer’s and small vessel disease on fiber tract changes in older adults: doi.org/10.1093/brain/…

Our new paper shows polygenic risk score comprising 85 lead AD-risk SNPs to be associated with enhanced effect of amyloid on the rate of tau PET accumulation, and cognitive decline. Thanks to lead author Anna Rubinski & @rainermpg, Simon Frerich Nico Franzmeier tinyurl.com/576vd4um

Excited to share our new work in EMBO Mol. Medicine🧠🧪 We show that earliest Abeta abnormalities are associated with sTREM2-related microglial responses, which may drive p-tau elevations. Many thanks to Nico Franzmeier, MatthiasBrendel, Marc Suárez-Calvet 🧠🧪 🩺🌈 and many others! doi.org/10.15252/emmm.…