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We are delighted to preprint one of the most exciting projects from our lab that took a good 5 years. biorxiv.org/content/10.110… We detail the landscape of epigenetic regulators of HOX/MEIS activation discovered through an epigenetic CRISPR library screen. A thread (1/15).

Do you ever question prior decisions as you gain new information? Do you wonder if immune cells do too? Check out our KuehLab preprint about a flexible T cell decision-making strategy that enables robust and scalable control of immunological memory tinyurl.com/58mha28t (1/n)

I have a toddler and had no idea the booster had been authorized for use in this age group.

In 2 weeks, I'll be starting my position as an Assistant Professor at Mass Eye and Ear and Harvard Medical School! My goal is to foster a thriving research environment to study the molecular mechanisms underlying retinal degeneration. Check out amamotolab.com for info!

It's frustrating reading comp bio articles these days because many keep falling into the same pitfalls. Hard to know if the method actually works, or whether they messed up the evaluation. Here are some issues I've seen recently (w/o names):

Thinking about starting a podcast called Cry What Out? No advice, no success stories, just parents who have tried every goddamn thing validating other parents who have tried every goddamn thing & can still count the number of times they have slept through the night on one hand.

Exceptionally stoked to share our new work entitled “Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements” ! biorxiv.org/content/10.110…

Beautiful work (and beautiful tweetorial!) by some of the smartest, kindest scientists I know!! Flo Chardon and Troy McDiarmid are an exceptionally rigorous team, and have produced some really important, thought-provoking work here!

Excited to share our lab's latest preprint, led by Chengxiang Qiu, @bethkarenmartin & Ian Welsh of The Jackson Laboratory. We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup. Preprint: tinyurl.com/2nhe4mm9 1/n

Thrilled to share my work describing chromatin-context dependent regulation of prime editing and our effort in leveraging this knowledge to modulate prime editing outcomes. biorxiv.org/content/10.110… 1/21

We're hiring a senior scientist to tackle the challenge of assaying 10,000s of human variants across diverse cellular models. 🧬 ✂️🧪✂️ 🧬 crick.ac.uk/careers-study/… Please RT + DM if interested.

🎉Exciting news! Starting this summer, we're launching a groundbreaking lab at University of Washington! Unraveling & reconstructing mammalian germ cell & embryonic development using pluripotent stem cells, bolstered by the power of high-throughput genomics. Join us on this thrilling journey.

We're building an interdisciplinary team at our new lab at University of Washington! Open positions for postdocs, students, technicians. If genomics, stem cells, and embryonic development intrigue you, this is your call. Join us at the confluence of Brotman Baty, UW Genome Sciences, ISCRM at UW, and UW Department of Obstetrics & Gynecology.

I spent my PhD developing novel genomic technologies, and today I am extra excited to share the last bit of this work, which is a multiplex prime editing (PE) screening framework! (1/n) biorxiv.org/content/10.110…

Our new paper “A molecular proximity sensor based on an engineered, dual-component guide RNA” is out! We describe a strategy named “P3 editing” for controlling genome editing with Protein-Protein Proximity in human cells. Thread: (1/9) biorxiv.org/content/10.110…

We're hiring a software engineer at the Seattle Hub for Synthetic Biology!! Come work with me to help build pipelines for and analyze next-generation sequencing data. :) alleninstitute.org/careers/jobs/?…

New synthetic biology / molecular recording lab opening in the New York city, and we are hiring at all levels (research tech / grad student / postdoc), so please reach out to me via choij10 _at_ mskcc.org!

Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s4158…

Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to identify cell type specific regulatory elements is published! rdcu.be/dUnoq

New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4