From #GRC #cellbiologyoftheneuron to the HHMI Hanna Gray Fellows retreat - what a scientifically enriched week filled with terrific research, engaging conversations, and admirable people. Excited to get back to the bench and keep the momentum going 🔬

Can’t think of anyone more deserving than you, Lydia Grmai, PhD 🇪🇷🔬🎶! She was one of my first mentors when I started this academic journey back UMBC & instilled so much confidence in me as my senior student Meyerhoff advisor. A huge round of applause for Lydia and so excited for you 🍾🎊

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… @Gustavo_SFranca

Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes: cell.com/neuron/fulltex…

Major props to Cellas A Hayes, PhD for spearheading this effort to showcase how the postdoc experience can be reimagined to recruit/retain those pursuing academic science. And a major thank you to Stanford Propel for supporting us with the ultimate goal of diversifying the professoriate.

Lysosomes drive the piecemeal removal of mitochondrial inner membrane | Nature nature.com/articles/s4158…

Our latest preprint! Some beautiful cell biology in this one. "Presynapses are mitophagy pit stops that prevent axon degeneration" biorxiv.org/cgi/content/sh… Discoveries into the cell biology of of mitophagy in axons, a disease mechanism, and a potential therapeutic avenue. 1/2

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP ⁦Gestwicki Lab⁩ ⁦Institute for Neurodegenerative Diseases⁩ nature.com/articles/s4146…

I’m amped to share our new work to decrypt transcriptional repressors, now on bioRxiv: biorxiv.org/content/10.110… We paired deep mutational scans with machine learning to predict and even tune repressor activity. (1/8)

New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors Marine Berquez Alex Li & Matthew Luy. Details below 👇 biorxiv.org/content/10.110…

How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/articl…

How does mitochondrial dysfunction in one cell impact neighboring cells? This study by Yipeng Du, Matthew Sieber et al. UT Southwestern Medical Center shows that mitochondrial ROS production regulates membrane receptor trafficking and disrupts cell-cell signaling. hubs.la/Q02Y4N0Q0

Grateful for this wonderful opportunity to present research from my grad and postdoc work and for allowing me to engage with the Vanderbilt Cell and Developmental Biology community. An extra thank you to Vivian Gama and Kris Burkewitz for the invitation 🙏🏽

The development of programmable antigen-gated G-protein-coupled engineered receptors (PAGERs) is published today! nature.com/articles/s4158… PAGERs couple detection of a wide range of custom-defined antigen to a variety of output including transgene expression and cell signaling.

Yay! Check out our new review on Turning garbage into gold: Autophagy in synaptic function sciencedirect.com/science/articl…

Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists! This cohort includes scientists working in research areas ranging from treatment-resistant cancers to sleep dysregulation to how

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease: nature.com/articles/s4155…

ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses: …arneurodegeneration.biomedcentral.com/articles/10.11…

Different types of mitochondria transit between cells Featuring work by Jon Brestoff and other contributors to this exciting field nature.com/articles/d4158…

🧠Have you ever cried when your #iPSC transgene vanished after differentiation? Yeah, we’ve cried too, and built a solution. Our PiggyBac vector keeps expression stable even after differentiation! Check out our #preprint👇 🔗 biorxiv.org/content/10.110… Supported by CZI Science