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First Pathania Lab paper in Cancer Discovery: bit.ly/3K5xA3J. We developed 16 mouse models of various subtypes of pediatric high-grade glioma— mirroring their different H3 mutant contexts, anatomical compartmentalizations and co-segregating partner alterations. Thread below 1/17

So happy to present our data on pediatric high grade gliomas at the pediatric SNO conference in Washington DC!

New #JITC article: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma bit.ly/3QKjNVd

Lab retreat in Siena, Tuscany! Antonella De Cola, Michael McNicholas, Lucie Pepino, Amelia, Carmo and friends

A few more from our team bonding trip to Tuscany!

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Biological, Diagnostic, and Therapeutic Insights from (Epi)Genomic Profiling of Pediatric Brain Tumors | Annual Reviews - go.shr.lc/3xgkNci Happy to share that our review is now online on Volume 8 of Annual Review of Cancer Biology! Manav Pathania | @manavpathania.bsky.social

Our paper where we characterize the immune TME of oncohistone gliomas is out Nature Communications. We applied transcriptomic, proteomic and spatial single-cell approaches, and multiple syngeneic mouse models nature.com/articles/s4146… 🧵1/