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Great talk at #ACR2024 on transcriptomic analysis from Michelle Kahlenberg on non-lesional skin biopsies of patients with incomplete #SLE. Cutaneous IFN scores at the spatial level -especially in the endothelium- were associated with higher ANA titre (>1:80) and anti-SSA antibodies,

Rituximab or cyclophosphamide for remission induction in #ANCA #vasculitis? Consider #rituximab in patients with relapsing disease or for fertility concerns in young patients. #cyclophosphamide seems to be the go-to option for life-threatening disease. #ACR2024 #rheumatology

Fantastic talk by Philip Seo at #ACR2024 on #ANCA #vasculitis: 1️⃣Plasma exchange does NOT improve renal survival 2️⃣Reduced steroid regimens may NOT account for life-threatening disease 3️⃣Unclear data on #rituximab/#cyclophosphamide combination 4️⃣#avacopan may help in granulomata

Clinical & subclinical #atherosclerosis occur at higher rates in #rheumatoid #arthritis. #Inflammation can be shown in arteries of affected organs & presumably contributes to accelerated ASCVD. #DMARDs reduce vascular inflammation ➡️Aggressive control of CV risk factors. #ACR2024

Occult RV failure in #scleroderma is hard to detect - identifying early maladaptive changes remains a clinical challenge. Earlier detection of RV dysfunction using common imaging modalities can lead to earlier diagnosis and treatment of pulmonary arterial #hypertension. #ACR2024

The use of cardiac MRI is an excellent tool to assess #cardiomyopathy in rheumatic diseases such as #SLE. #Lupus #myocarditis can be a severe life-threatening manifestation & multiparametric cardiac MR should be performed to evaluate the extent & pattern of involvement. #ACR2024

🤔Is #glucocorticoid withdrawal possible in sustained inactive SLE patients? 👆 This study says yes, but better to keep hydroxychloroquine! Relapse rates 👉 GC and HCQ withdrawal 26.1% 👉 discontinued GC but maintained HCQ 11.2% 👉GC and HCQ continued 4.7% ard.bmj.com/content/early/…

New online! An update on autoantibodies in the idiopathic inflammatory myopathies go.nature.com/4g2IF4x

New online! The ‘Treg paradox’ in inflammatory arthritis go.nature.com/3OMjE1q

Many congratulations to Ed Vital for being appointed Professor of Translational Medicine at University of Leeds! #Rheumatology #lupus #SLE

🎉Congratulations to Laura Coates, who is the first rheumatologist to be awarded an NIHR Research Professorship! ndorms.ox.ac.uk/news/laura-coa…

New content online: Opportunities and limitations of B cell depletion approaches in SLE bit.ly/4jixPJn

Early transcriptional effects of inflammatory #cytokines reveal highly redundant cytokine networks. New resource from Juliana Lee, Christophe Benoist Harvard Medical School and colleagues: hubs.la/Q034kYxW0 #LymphocyteBiology #InnateImmunity #inflammation

The number of clinical academics has been declining in the UK since 2012 and there are many factors causing this huge problem for #NHS and #universities ⬇️

To all friends and colleagues attending the 10th symposium of systemic #autoimmune diseases in Santander, I will be presenting in the satellite session on the role of type I #interferon in the pathogenesis of #lupus. Come and say hi!

Great work on PARP7 and its role controlling type I interferon mediated autoimmunity ⬇️

NEW REVIEW—Lucy Marie Carter, Michael Ehrenstein & Ed Vital discuss the evolution and trajectory of B-cell targeted therapies in rheumatic diseases bit.ly/4hfPCP8

Thank goodness people are waking up to the fact that there is a crisis for clinical research in the UK Financial Times High on the list are the bureaucratic processes that have become such an obstacle to getting things done

New content online: Arterial and venous thrombosis in systemic and monogenic vasculitis bit.ly/4jGofjg

💜 It's #WorldLupusDay! We stand with the 5 million people worldwide living with lupus. We’re dedicated to providing accessible resources to support clinicians and improve patient care. Explore our lupus resources here 👉ow.ly/nblQ50VNssh