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Three more surprises from the FDA decision on aducanumab: 1) Approved for Alzheimer’s disease, no restriction on disease stage. 2) No requirement for amyloid-PET, CSF analysis or APOE testing. 3) OK to continue, even after severe ARIA-H if imaging looks stable.

É falso que as vacinas contra Covid-19 contêm ímãs e podem gerar magnetismo após a aplicação, conforme alegam vídeos que circulam em redes sociais. Os veículos de checagem já divulgaram que se trata de Fake News. O Butantan repudia a disseminação de notícias falsas. #Podeconfiar

O besouro-tartaruga existe pra provar que insetos também são fofos *tem um monte desses aqui no Brasil 💚

🚨 Bióloga Natalia Pasternak desmonta de uma vez por todas a loucura da #hidroxicloroquina como forma de combate à #covid19 @jairmessiasbolsonaro e o gabinete paralelo precisam serem responsabilizados. Vídeo: @metropoles

O negacionismo mata!! Por favor, usem máscara! Na dúvida busquem informações em fontes confiáveis e com base na ciência!

The best of Brazil. Viva São João!

Something new from the lab today — Lissa Ventura Antunes took a picture of an arteriole in a human brain degenerating due to cerebral amyloid angiopathy. #vumcneuro @VUMCneurology VanderbiltPostdoctoralAssociation @VanderbiltAlz Vanderbilt Cell Imaging Shared Resource Alex Nackenoff, Ph.D. Cerebral Amyloid Angiopathy #endalz

Want to see something cool? These are astrocytes interacting with small blood vessels in human grey matter from a patient with cerebral amyloid angiopathy. Images by Lissa Ventura Antunes, Zeiss lightsheet. @VUMCneurology @VanderbiltAlz #vumcneuro Vanderbilt Cell Imaging Shared Resource ZEISS Microscopy

Here's a dramatic picture of an artery that ruptured due to cerebral amyloid angiopathy; residual, fractured beta-amyloid shards are stained red. Credit: Lissa Ventura Antunes. @vumcneurology #vumcneuro @VanderbiltAlz Vanderbilt Brain Institute Vanderbilt Cell Imaging Shared Resource

I always pictured astrocytes as dainty little cells. Lissa’s pictures from human brain show many astrocytes are quite large. They span multiple blood vessels and link many neurons. Astrocytes in red (GFAP), vessels green, another protein we’re studying in purple. Lissa Ventura Antunes

Here it is, fresh off the press! If blood flow in the brain were adjusted in development to meet the demands of neurons, there should be more capillaries where there are more neurons - but no: capillary density is what it is, neurons just must make do. frontiersin.org/articles/10.33…

Important reporting from Charles Piller Charles Piller putting the spotlight on research integrity in Alzheimer’s research. science.org/content/articl…

Happy to participate at my first AD conference at #AAIC2022

Excited to present my poster today on “ 3D Morphology of Degenerative Arteriolar changes in CAA” If you are at #AAIC22 come to my poster (P4-097) to chat! SchragLab

Because capillary density varies little in the brain, sites with fewer, larger neurons supply more energy per neuron than sites with more, smaller neurons. We propose that the latter, like the hippocampus, are more vulnerable to aging and disease frontiersin.org/articles/10.33…

We have had the incredible privilege of studying the brain of a patient who died after three doses of Lecanemab/Lequembi. This striking case has intense cerebrovascular inflammation/degeneration. We are so grateful to her family for sharing her story w the scientific community.

Happy to share one of my images on that case report! Clinical trial participant’s autopsy and brain exam stoke Alzheimer’s drug fears science.org/content/articl…

New preprint from our group, led by Lissa Ventura Antunes, explores structural changes in arterioles with cerebral amyloid angiopathy. Lissa is a master of quantitative 3D microscopy. In this clip, healthy tissue is first, then two cases with CAA. @VUMCneurology Vanderbilt University Medical Center

As the vessels deteriorate, the lumen expands and the organized rings of beta-amyloid start to fracture into sharply contoured "shards." Vanderbilt Cell Imaging Shared Resource

We explore a potential role for the extracellular matrix modifying enzyme LOX in CAA, showing it correlates with degenerative phenotypes. LOX (in pink) could mediate the increased vascular stiffness and structural distortion we observed in CAA by crosslinking ECM proteins.