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» Host-encoded DNA methyltransferases modify the epigenome and host tropism of invading phages: iScience cell.com/iscience/fullt…

The sequel to our DRT2 story is here, and this one is once again full of surprises! This time around, the Sternberg Lab teamed up with the Wiedenheft Lab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: biorxiv.org/content/10.110…

Sisi Lin (Shanghai Jiao Tong University) and colleagues published a new paper on coating #phage-infected bacteria with polymers, showing this preserves phage vitality and improves therapeutic outcomes in mouse models of bacterial infection compared to uncoated phages. buff.ly/V4cKbNb

biorxiv.org/content/10.110… We found ubiquitous recombinases from cryptic prophages may invert DNA to form new, chimeric proteins that inhibit phages by blocking adsorption. Congratulations to Joy, Daniel, Rodolfo and Michael for their strong efforts.

3rd UK MGE Workshop – June 16-17, Southampton Low-cost, science-focused, and full of fresh faces! Great discussions—no hidden agendas, just MGEs. Call for talks– No abstract needed! Just send your title by the end of April. #MGE #UKscience

A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins biorxiv.org/content/10.110… #biorxiv_micrbio

Stealth plasmids: rapid evolution of deleted plasmids can displace antibiotic resistance plasmids under selection for horizontal transmission. | bioRxiv biorxiv.org/content/10.110…

A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins | bioRxiv biorxiv.org/content/10.110…

END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes | bioRxiv biorxiv.org/content/10.110…

.Yuping Li (UC San Francisco) and colleagues published a new paper on a bacterial immune system targeting jumbo #phages, showing it disrupts an early phage infection compartment to block replication. buff.ly/GcJz6oO

Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery biorxiv.org/content/10.110… #biorxiv_micrbio

doi.org/10.1038/s41467… Another example of phage defense by TAs via transcription shutoff confirming the 1996 Hok/sok paradigm. This time, probable type IV ShoT/ShoA inhibits phage by altering purine metabolism via ShoT phosphoribosyltransferase activity.

Completing the BASEL phage collection to unlock hidden diversity for systematic exploration of phage–host interactions | PLOS Biology journals.plos.org/plosbiology/ar…

Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…

Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA: Molecular Cell cell.com/molecular-cell…

Rapidly evolving orphan immunity genes protect human gut bacteria from intoxication by the type VI secretion system biorxiv.org/content/10.110… #biorxiv_micrbio

"Phollow" the link to our May issue to read about... 💥lysing bacterial pathogens ⛽microbial alkane oxidation 🌱importance of seed-borne bacteria 🙅‍♀️protective antibodies for norovirus 🚰E. coli in urban drinking water ...and more!👇 nature.com/nmicrobiol/vol…

Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential biorxiv.org/content/10.110… #biorxiv_micrbio

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…

Out now in Molecular Cell: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA cell.com/molecular-cell… Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein? A 🧵