Nice work from our neighbours and collaborators here in the CSCB/ @bmssheffield together with Tariq Enver's group on how to "trap" a human mesoderm-biased pluripotent stem cell state through WNT signalling fine-tuning: biorxiv.org/content/early/…

Exciting PhD opportunity with the up and coming PI of the moment Dr Guilherme Costa. If you are interested in RNA localisation, angiogenesis or ideally both then you should check out this fantastic opportunity: findaphd.com/phds/project/r…

Latest preprint by Tom Minchington @samgriffjon decomposes gene regulation into simple motifs showing that dual feedback motifs (auto-regulatory TF+microRNA) are prevalent and thus could drive dynamic expression in many genes found in human. biorxiv.org/content/10.110…

How do cells make cell state transitions? Papalopulu Lab Ximena Soto et al reveal a #miRNA-driven mechanism counteracting noise and ensuring oscillatory expression of transcriptional regulators during #zebrafish neurogenesis embopress.org/doi/10.15252/e…

WE’RE HIRING! Are you a cell or developmental biologist? Are you interested in how cells coordinate multiple processes during tissue morphogenesis? Join our team! We’re looking for TWO new research associates! nature.com/naturecareers/… #sciencejobs #postdoc jobRxiv the Node

Cells in tissue are using ‘group chats’ to make decisions! Multiscale synthesis of fine-grained protein expression of HES5 reveals locally co-ordinated clusters and stripes that control rate of progenitor differentiation. bioRxiv: biorxiv.org/content/10.110… 1/5

I'm excited to share my first first-author publication that is out now in Developmental Cell. An exciting collaboration between The Ashe lab, @MagnusRattray and Tom Minchington. We show how the Drosophila embryo decodes the BMP signaling gradient at single-cell resolution. (1/7)

Excited to see that my first, first-author paper with @samgriffjon and Papalopulu Lab is now out! Do you work on dynamically expressed proteins? Probably. Check to see if your favourite transcriptional regulator features in our results. nature.com/articles/s4159…

In the latest preprint a phase-dependent relationship between Hes1 and cell-cycle is shown to underlie #cellcycle length heterogeneity in ER+ #breastcancer cells. Congratulations to the authors Nitin Sabherwal Andy Rowntree Jochen Kursawe nancy papalopulu biorxiv.org/content/10.110… 1/6

A new preprint from us! We use the SunTag system to image translation from single mRNAs in the Drosophila embryo and uncover translational regulation of the zygotic hunchback mRNA. Work by Daisy Vinter, Caroline Hoppe, Cath Sutcliffe, and Tom Minchington biorxiv.org/content/10.110…

We are looking for a talented, self-motivated and collegial post-doc, with passion for #liveimaging, molecular biology expertise and a desire to understand the mechanisms of #cellstatetransitions in #development and #cancer. Apply before June 10th! jobs.manchester.ac.uk/internal/displ…

The day is FINALLY here! The green light has been given by Swedish authorities for a first-in-human clinical trial with the stem cell therapy STEM-PD for treatment of Parkinsons disease! cam.ac.uk/research/news/… Parmar Lab Cambridge Stem Cell Institute Brain Repair VGB Agnete Kirkeby

🚨we’re looking for a Postdoc (2-years initially) 🐭⌛️ 📩 drop an email for further info Closes Jan 31st

Yay my decoding NGN3 #oscillations paper is now in review, fingers crossed for a friendly reviewer 3 🤣

!!Job advert alert!! We are looking for an enthusiastic postdoc with molecular biology expertise and a strong interest in developmental and/or cancer biology to join our team. Apply before Feb 5th: thenode.biologists.com/jobs/post-doc-…

We identified that the #SOX2 protein oscillates every 17h in proliferative and quiescent #glioblastoma stem cells. Interestingly, the #OscoNet algorithm predicted thousands more genes to oscillate 🤯 Our paper is out: nature.com/articles/s4159…

Our innovative study brings out the distinction between single cell and population-level #dynamic regulation. Single cell #oscillators can behave abnormally, despite this the population is normal due to cell #coupling mediated compensation. Development journals.biologists.com/dev/article/15…