
Aoi Otsuka
@aoi_otsuka_
PhD student @kazu_maeshima lab, in @NIG_idenken.
ID: 1674724166594068481
http://maeshima-lab.sakura.ne.jp 30-06-2023 10:19:04
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30 Followers
36 Following


I received a poster award at the 3rd Symposium of Physical Biology and Biological Physics! Thanks to everyone, especially to my supervisor Kazuhiro Maeshima for his support and encouragement. I'll do my best in future!


My Ph .D student Aoi Otsuka won the First-place Poster Award at the Physical Models of Living Matters Symposium held in Taoyuan, Taiwan. Congratulations! indico.phys.sinica.edu.tw/event/106/



Symposium "Physical Models of Living Matter" in Taiwan, led by Keng-hui Lin, concluded successfully! In the closing remark, we presented poster awards to Aoi Otsuka, Sokendai in Japan Ting-Jui Ben Chang, Nat'l Taiwan U Jen-Hao Cheng, Academia Sinica Sincere congratulations, all!!


My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.110… Huge thanks to my PI, Kazuhiro Maeshima, for supervision. Amazing collab with Rosana Collepardo’s group!" (1/n)

Our new preprint is out@bioRxiv: biorxiv.org/content/10.110… Masa A. Shimazoe et al. reveal that linker histone H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with Rosana Collepardo, Charlie Phillips, Jan Huertas and others—huge thanks! 🙌 1/2

Our new paper is out Science Advances👇 science.org/doi/10.1126/sc… 🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells. 🔍Katsuhiko Minami et al.have developed a chromatin behavior atlas within the nucleus. 1/2





Our new review paper is out @ JMB! 🧬 Katsuhiko Minami Adilgazy Semeigazin, MSc よしこりあん discuss DNA accessibility in euchromatin and heterochromatin in living cells. 📘 Free access: authors.elsevier.com/a/1lHgb54HFZNbb 🔗 Also, check our previous paper on nucleosome motion: science.org/doi/10.1126/sc…


Now in Cancer Cell our group reports the development of a first-in-class EGFR-directed KRAS G12V selective inhibitor. KRAS G12V mutations are the 2nd most common KRAS mutation in cancer, and there are still no approved inhibitors in the clinic. We address two major challenges




🧵Thrilled to share my first-author paper published in J Cell Science Title: A single-chain antibody-based AID2 system for conditional degradation of GFP-tagged and untagged proteins (1/🧵) doi.org/10.1242/jcs.26…

Our new work bioRxiv 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. Adilgazy Semeigazin, MSc Katsuhiko Minami Masa A. Shimazoe