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I attended the 3rd Symposium of Physical Biology and Biological Physics in Taiwan! At this conference, I discussed with many people from physics, math, material and biology. I enjoy the discussion at my first international conference!

I received a poster award at the 3rd Symposium of Physical Biology and Biological Physics! Thanks to everyone, especially to my supervisor Kazuhiro Maeshima for his support and encouragement. I'll do my best in future!

My Ph .D student Aoi Otsuka won the First-place Poster Award at the Physical Models of Living Matters Symposium held in Taoyuan, Taiwan. Congratulations! indico.phys.sinica.edu.tw/event/106/

【受賞】総研大生･大塚碧さんが「First-place Poster Award」を受賞いたしました🏅 nig.ac.jp/nig/ja/2024/09… ■研究室 nig.ac.jp/nig/ja/researc…

Aoi Otsuka won the First-place Poster Award. nig.ac.jp/nig/2024/09/in…

Symposium "Physical Models of Living Matter" in Taiwan, led by Keng-hui Lin, concluded successfully! In the closing remark, we presented poster awards to Aoi Otsuka, Sokendai in Japan Ting-Jui Ben Chang, Nat'l Taiwan U Jen-Hao Cheng, Academia Sinica Sincere congratulations, all!!

Our new review on how the #chromatin domain is formed in the cell is out @ Curr Opin Struct Biol.📄✨ We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation. 📥 Free-download link: authors.elsevier.com/a/1keGn,LqArXq…

My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.110… Huge thanks to my PI, Kazuhiro Maeshima, for supervision. Amazing collab with Rosana Collepardo’s group!" (1/n)

Our new preprint is out＠bioRxiv: biorxiv.org/content/10.110… Masa A. Shimazoe et al. reveal that linker histone H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with Rosana Collepardo, Charlie Phillips, Jan Huertas and others—huge thanks! 🙌 1/2

Our new paper is out Science Advances👇 science.org/doi/10.1126/sc… 🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells. 🔍Katsuhiko Minami et al.have developed a chromatin behavior atlas within the nucleus. 1/2

ヒトの細胞に葉緑体を取り込ませる実験。面白いっすね。 Examining interactions of animal cells with chloroplasts and their light-induced responses in in vitrocell culture systems sciencedirect.com/science/articl…

🧬My retrospective chromatin review is out@Proc Jpn Acad: doi.org/10.2183/pjab.1… Textbook models of 30-nm fibers are fading. A new paradigm: chromatin forms liquid-like domains—locally dynamic, yet globally stable at chromosome level (viscoelastic)—supporting genome function.✨

Nature research paper: Multigenerational cell tracking of DNA replication and heritable DNA damage go.nature.com/4mGMBLY

I attended the 28th 3R workshop 2025 in Atami! At this workshop, I discussed with many researchers who have various research background (not only cell biology, but also molecular genetics). I enjoyed the discussion during the presentation, lunch, dinner, and night party!

Our new review paper is out @ JMB!　🧬 Katsuhiko Minami Adilgazy Semeigazin, MSc よしこりあん discuss DNA accessibility in euchromatin and heterochromatin in living cells. 📘 Free access: authors.elsevier.com/a/1lHgb54HFZNbb 🔗 Also, check our previous paper on nucleosome motion: science.org/doi/10.1126/sc…

Now in Cancer Cell our group reports the development of a first-in-class EGFR-directed KRAS G12V selective inhibitor. KRAS G12V mutations are the 2nd most common KRAS mutation in cancer, and there are still no approved inhibitors in the clinic. We address two major challenges

Cancer may leave its mark in the blood years before people are diagnosed with the disease. sciencenews.org/article/cancer…

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis go.nature.com/3HYTQie

🧵Thrilled to share my first-author paper published in J Cell Science Title: A single-chain antibody-based AID2 system for conditional degradation of GFP-tagged and untagged proteins (1/🧵) doi.org/10.1242/jcs.26…

Our new work bioRxiv 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. Adilgazy Semeigazin, MSc Katsuhiko Minami Masa A. Shimazoe