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ICYMI 📣Application of reprogrammed bacteriophage to functional metagenomics improves identification of antibiotic resistance genes Balint Kintses GáborApjok BalintKintsesLab @tamas_stirling csaba pal nature.com/articles/s4156…

The latest work from our lab answers a question we have been asked many times. Why do mammalian cells uptake bacteriophage? The quick answer - cells are eating the phages! See below for details on this work that was led by our PhD graduate Marion Bichet

We start by showing that our cell lines rapidly internalised bacteriophage T4, which is shown here fluorescence labelled in green while being engulfed by a mammalian cell over a ~1hr period. Importantly, phages accumulate inside cells in high numbers for long periods of time.

That's the reason I love #electronmicroscopy You can see cool stuff like this :D Any ideas what's going on here?

If like me you like to analyse genomics data in Jupyter notebooks I have something for you: dbikard.github.io/genomenotebook/

Genetic Engineering 1993 We were right, they were wrong. 2003 We were right, they were wrong. 2013 We were right they were wrong. 2023 We are right, they are wrong. We have three decades of being trashed by enemies of science. Why do people still believe them? #GMO

Our collaboration with YSBL University of York resulted in this stunning atomic resolution structure of (nearly) complete virion of crAss001, a crAss-like phage. Huge congrats and thanks to Oli Bayfield, Fred Antson, and all co-authors on this paper! nature.com/articles/s4158…

Excited to share our work using phages to identify bacterial pathogens in sepsis. Because phages are highly specific for their bacterial hosts, they offer strain-level resolution that could enhance cell free DNA diagnostics nature.com/articles/s4156…

I was asked if I can review a manuscript for Nature Communications. They charge authors 6250 USD APC. I am expert in field they request me to review. It will take me at least full day of work because field is pretty complex. I want to ask for 2000 USD for the job. Your opinion?

This is what viral diversity looks like! biorxiv.org/content/10.110… Together with our EM wizard Ulrike Mersdorf at Max Planck Institute for Medical Research and Jeff Blanchard at UMass Amherst, I am thrilled and proud to present our latest work on virus-like particles on soil! (1/7)

NEW EPISODE OUT! 📢 In our latest episode, we had the pleasure of discussing groundbreaking research with Rob Lavigne, a renowned Professor in the Faculty of Bioscience Engineering of the KU Leuven, leading the Laboratory of Gene Technology.

To all at #vom2023 - hope it's fun! Don't forget the first mass-market book on microbial viruses has just been released and is available to buy now: amazon.co.uk/gp/aw/d/152936…

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Posters up - section A row 16 - come say hello at 12 (will have to duck off at 12:30...) Now in hall J for GCPR talk! Phage Australia - Connect. Discover. Cure Iredell Lab Global Clinical Phage Rounds #ESCMIDGlobal2024

Alyssa is the first patient to receive a base edited therapeutic (triply base edited CAR-T cells that cleared her T-cell leukemia), doing well now more than two years post-treatment thanks to the efforts of Waseem Qasim’s team and GOSH.

Well done to Holly Sinclair and Dr. Rabeya Rahmatullah 🐟🦠🧫🧬👩‍🔬🇧🇩🇦🇺 on their poster presentations today at #VoM2024! It’s great to see the working done from biomanufacturing therapeutic phages to treating infections in patients! Phage Australia - Connect. Discover. Cure Iredell Lab

Thank you to the organisers Viruses of Microbes 2024 Jeremy J Barr & Ruby Lin for an incredible meeting, my first VoM! The opportunity to meet and learn from leading phage researchers was so memorable, can't wait for Prague! Phage Australia - Connect. Discover. Cure Iredell Lab Stephanie Lynch, PhD

The terrifying beauty of the ocean 🧵 1. Sitting on the edge of an underwater cliff