Hey folks, I know most deadlines are fast approaching, but I am applying for assistant professor positions this cycle, and I would appreciate recommendations for open positions! My research plan is focused on MGEs, genome engineering, and applying AI to biological discovery.

excited to share COMET! A scalable CRISPR approach we (Caroline Wilson) developed to identify multidomain proteins that modulate transcription at specific endogenous genomic loci. Arc Institute @ucsf doi.org/10.1101/2024.1…

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

🧬 Thrilled to share our latest work on engineering precise DNA recombinases for targeted genome integration! Through directed evolution & protein fusions, we achieved over 50% efficiency & 97% specificity for multi-kb DNA cargo insertions. Big thanks to all co-authors -

🚨 Early Bird Registration extended to Friday 22 November! 🚨 Don't miss out on the discounted rate—REGISTER NOW! 🔗 crispr2025.org/registration #CRISPR2025 #CRISPR #Phage

Starting our Arc Science Fellow info session in less than an hour!

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, Arc Institute in collaboration with NVIDIA releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life 🧵

We're excited to announce Arc Institute's search for a Chief Scientific Officer to help advance our mission of accelerating scientific progress on complex human diseases. Arc combines cutting-edge experimental biology with computational methods—from our Evo 2 biological

We made an AI agent go vroom on all of SRA to create scBaseCamp, Arc Institute's ever-expanding and uniformly processed single cell data repo! 230M cells drawn from 21 species, 72 tissues, and counting... arcinstitute.org/manuscripts/sc… x.com/yusufroohani/s…

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Read the full preprint below 👇 If you're interested in the interface of bioengineering, DNA and virtual cell foundation models, and agentic reasoning, shoot me a note. We're hiring postdocs and ML researchers and starting some crazy new projects biorxiv.org/content/10.110…

"Does it work in human cells?" is a question I've gotten a lot this past year. Excited to share our latest work on bridge recombinases! It's been a lot of fun to lead this team effort. If you are excited to hear more, join for my thesis defense tomorrow at 3pm PT. Links below:

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. nature.com/naturecareers/… Please repost!

excited to join this panel for a free webinar on the journal editor career path hosted by Life Science Editors, coming up on October 7. scan the QR code in the image or visit lifescienceeditors.com to learn more and register!

New from Arc Institute: Megabase scale genome-editing in human cells. Bridge recombinases are a new class of genome editors. In this paper, they were used to invert up to 920,000 base pairs of DNA and also cut out 130,000 base pairs, "with no apparent distance dependency." Let

Excited to share that my PhD thesis work is out in Science Magazine today. We demonstrate robust rearrangement of the human genome using bridge recombinases, performing programmable insertions, excisions, and inversions at megabase-scale.

Today in Science Magazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The

register to join us tomorrow!!

Arc is looking for an outstanding early-career scientist to be our next Science Fellow. This program provides resources and freedom for those looking to transition into a principal investigator role immediately after doctoral training. Apply here: arcinstitute.org/programs/searc…