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#IDtwitter don’t forget about pemivibart! This is so important for all those immunocompromised pts, particularly the ones on CD20 inhibitors (rituximab, obinutuzumab, ocrelizumab). Was surprised to see the effect at 12 months! NNT=7 doi.org/10.1093/cid/ci…

We need a lot of things to make people healthier but taking away vaccines (especially those with significant data of saving millions of lives) is not one of them

Very insightful and thoughtful assessment! These are the constructive discussions physicians and researchers need to be having on this platform instead of seeking retribution- that rhetoric doesn’t help anyone esp the sick.

Very interesting study. Stem cell transplantation as a successful therapy for a subset of IBD patients. Would certainly help a lot of people undergoing a lot of suffering.

Yet another reason not to overuse antibiotics that are not necessary. Anaerobic empiric therapy not needed if infection suspected in an area without anaerobes! And certainly de escalation as appropriate.

Would be important for Secretary Kennedy and health admin to see this. For all people claiming vaccines aren’t RCT tested vs placebo, take a look. The data is all there…with 260 trials and 2.5million patients randomized. There is simply no argument to overwhelming data.

The only thing this does is it may make a few people feel better about eating a highly unhealthy food. It’s certainly not making anyone any healthier.

Hep c cure rate now approaching 100% with amazingly minimal side effect profile. Truly incredible progress in this field. No one should be suffering due to hep C.

It’s been well demonstrated that beta lactams (now specifically cefazolin) should be used over vancomycin for MSSA and here’s another meta analysis. Using vanco would be an inferior treatment strategy.

Wow. May be better to prevent disease, no?

Important to have prophylaxis in very high risk patients. Pemibivart seems to work very well for Covid, with relatively low side effect profile.

“In the absence of data, they should talk to their doctor”….that’s FDA guidance??? So then what is their doctor supposed to say? Genuine question. I guess this is the new gold standard medicine.

It’s also more than likely you don’t have a UTI if it was diagnosed in the hospital

Not surprising that cocci cases are increasing, am seeing it very frequently. With climate change cases continue to rise. Important for early diagnosis, and eventually, newer treatments as resistance develops.

Never blindly follow consultant recs. This removes critical thinking from people who may know the pt and case better. Typically a full discussion should be had unless case is relatively straightforward - though even still communication is key.

Great analysis. Exercise is good but the effect size cannot be greater than cancer therapy itself! Important to point out physical fitness helps improve outcomes in many areas of medicine. Frailty prior to transplant has been independently linked to poor outcomes, as an example

Excellent work, worth reading and reviewing for all those saying vaccines have not been subject to placebo controlled trials, especially HHS sec Secretary Kennedy

Synthesis of the available literature on the use of CMV-specific T-cell therapy in adult and pediatric HSCT and SOT recipients. Several patients on concurrent antivirals, which confounded the effectiveness of VSTs Clinical Infectious Diseases transplantid.net academic.oup.com/cid/advance-ar…

Would first determine if truly a UTI and not asymptomatic bacteriuria - most commonly seen in such resistant bugs because of prior over treatment. If true UTI - multiple options incl cefiderocol, ceftol-tazo, fosfomycin. Newer drugs on horizon as well.

Yes unnecessary and over-use of antibiotics is a huge problem. Leads to this..