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1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! biorxiv.org/content/10.110…

New Online! An evolving landscape of PRC2–RNA interactions in chromatin regulation bit.ly/3ENcE2T

Native nucleosomes intrinsically encode genome organization principles. #Nucleosomes #GenomeArchitecture nature nature.com/articles/s4158…

🚨NEWS! 🚨 Interested in which genes are the true effectors behind the scenes of the #gwas results? This new publication in Nature Genetics focuses on approaches to predicted effector gene reporting tinyurl.com/98yxy4hf (1/3) 👇

Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging. A few of the most exciting papers, a 🧵:

Introducing CondenSeq, an imaging-based high-throughput approach for characterizing protein condensates within the nuclear environment. Kalli Kappel nature.com/articles/s4159…

Glad to see this paper finally out! An episodic burst of massive genomic rearrangements and the origin of non-marine annelids NatureEcoEvo Institute of Evolutionary Biology (IBE) Metazoa Phylogenomics Lab CSIC European Research Council (ERC) nature.com/articles/s4155…

How do non-coding variants in enhancers cause human disease? Here, in my main PhD work with Evgeny Kvon, we uncover a surprising mechanism, with generalizable implications for human genomics. tinyurl.com/89tdkevu n/

How nerve cells transfer their powerhouse mitochondria to fuel cancer cells nature nature.com/articles/d4158… nature.com/articles/s4158…

Happy to share that our latest study is now out in Nature! Cancer cells steal mitochondria from neurons to boost metabolism, resist stress & spread. We built MitoTRACER to trace & tag these transfers in vivo. nature.com/articles/s4158…

New online! Structural variants in the 3D genome as drivers of disease bit.ly/44FiIo5

AbbVie bags Capstan’s in vivo CAR-T work with $2.1B buyout deal - endpoints.news/abbvie-bags-ca…

Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in nature. nature.com/articles/s4158…

Our scMicro-C paper is out in Nature Genetics! Huge thanks to the reviewers for their valuable insights, to SunneyXie for unwavering support, and to fantastic collaborators Jiankun Zhang & Longzhi Tan. Thrilled to share this work!

Excited to share that my PhD work is out in nature today! We engineered armoured CAR T cells to express therapeutic payloads only at the tumour site, to improve their safety and efficacy for the treatment of solid cancers. 1/14 nature.com/articles/s4158…

Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.

Our new work bioRxiv 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. Adilgazy Semeigazin, MSc Katsuhiko Minami Masa A. Shimazoe

Excited to share our latest work out now in print nature! Lead by @almudena_Chaves and @ScottMillman_MD, we uncover how metabolic rewiring via OGDH controls tissue regeneration and stem cell fate in the intestine 🚀🚨 bit.ly/44oaOiW

New Article! Fluorescence-activated particle sorting for condensate purification bit.ly/4lKN12T

Excited to share my first postdoc paper in Cell! We found that BRD4 transcriptional condensates act as a pH-sensitive “switch” to fine-tune inflammation. Huge thanks to my amazing mentors & collaborators!@XuZhouLab Ruslan Medzhitov Jonathan Kagan Ivan Zanoni