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At this time a fascinating paper from Danny Reinberg lab demonstrated differential histone dilution kinetics in active versus repressed chromatin during replication tinyurl.com/5n8vp3tn. The authors did not connect this to diffusion, but to me the signs were clear (4/8)

Together with Archit Singh, a fantastic student in my lab, we developed a lattice model for the replication fork with diffusive dynamics of histones. Incorporating larger diffusivity in active chromatin quantitatively recapitulated the previous experimental observations (5/8)

We then asked if we could use the computational model to predict signatures of histone diffusion that ought to be left behind in dividing cells. We predicted 3 distinct patterns for the similarity of histone marks between pairs of loci, in active and repressed chromatin (6/8)

Excitingly, we found all 3 predicted patterns in various histone mark ChIP-seq datasets from two different cell lines. Even more interestingly, the patterns were visible in inter-chromosomal loci pairs, suggesting histone diffusion across different chromosomes! (7/8)

This suggests that unlike the picture painted by current histone inheritance models, diffusion redistributes histones and their marks during replication, to a wider extent in active loci. Maintenance of precise spatial epigenetic patterns may therefore not be necessary (8/8)

Really nice to have been able to have a team retreat in person, not least in beautiful Paris just before #IGES22. Lots of time for scientific discourse and sampling of all that Paris has to offer:)

I'm excited to share our new fine-mapping methods: SuSiE-inf and FINEMAP-inf. We improve upon the current state-of-the art methods by modeling infinitesimal effects while fine-mapping larger causal effects. 🧵 1/n biorxiv.org/content/10.110…

We knew it! Thanks for doing the analysis and congrats for the publication (go.nature.com/3kJ8RZU) If you share your #SumStats you increase your citations and the impact of your research! Share your data bit.ly/38rNSjx #gwas #OpenAccess nature

Super excited for this incredible 3-day event to benefit AFSP. Look for the link to purchase your tickets tomorrow at 8am PDT. Thank you Warner Bros. for all your support helping to make this happen. #AFSP #FullCircle #Snyderverse #ArtCenter #WarnerBros #DC #AMCTheaters

An important paper on the genetic architecture of South Asians is published by a fantastic team of industry and academic researchers. I recommend you read the paper to learn about all the interesting findings. But here are some general thoughts. I am not involved in this study,

Very happy that our new work from Living Machines-NCBS National Centre for Biological Sciences on histone diffusion, challenging the conventional idea of 100% accurate histone-mark inheritance during replication, is now out in PLOS Comp Biol ! tinyurl.com/5hbnkaj2

Can we combine inhibitors of the #circadian clock and lineage correlations to detect presence of cell cycle gating by the clock? Excited about our new manuscript from National Centre for Biological Sciences, Living Machines-NCBS showing how this might be possible! A short thread (1/6) tinyurl.com/46pub9rh

The largest genome-wide association study for type 2 diabetes so far, which included several ancestry groups, led to the identification of eight clusters of genetic risk variants go.nature.com/3xzZ27i

Very happy to share our latest study on the metabolic consequences of T2D in the UKBB, using MR and interaction QTL analyses. This work uses metabolomics profiles to better understand T2D trajectory to complications.

Is it always possible to assign #GeneExpression #CellStates to #SingleCells? Or can biological noise set fundamental limits? In our new work, we show that #CircadianClock states *cannot* be assigned to single cells due to transcriptional noise! tinyurl.com/4uxdxw2k (1/8)

What I don't get about academia is the chronic lack of celebration. It is hard to get & maintain grant funding, hard to get papers accepted without Faustian bargains, hard to be a great mentor, & hard to maximize trainee success. All of it is hard. We should celebrate everything.

Scientists of ISRO

15 March 2025 Issue: academic.oup.com/hmg/issue/34/6 Cover: Type 2 diabetes complications impact various organs throughout the body. As shown in the figure, these complications are broadly classified into two major categories: microvascular and macrovascular. doi.org/10.1093/hmg/dd…