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Online now for the #AACR25 session on Advances in #KRAS Biology in PDAC by session speaker Andrew Aguirre: Response and Resistance to RAS inhibition in Cancer brnw.ch/21wSgTw

At yesterday's opening ceremony, we asked the cancer community to stand together to make their voices heard in support of innovative cancer science and medicine. #CancerResearchSavesLives® #AACR25

Frank McCormick in the Ras townhall at #AACR25 introducing BridgeBio‘s Ras-PI3K complex breaker BBO-10203. Derived from an insulin function mimetic glue by structure-based design. Yet another facette of modulating Ras biology with small molecules. Who called Ras „undruggable“? 😆

New work from ⁦Sandra Misale⁩ and team: Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations | Cancer Discovery | American Association for Cancer Research | #AACR25 aacrjournals.org/cancerdiscover…

🙌 hey #AACR25, don’t miss Dr. Yuki Matsunaga’s poster tomorrow at 2 pm! #singlecellseq #drugtolerance #CDK4/6i #breastcancer UTSW Simmons Cancer Center

Hey #AACR25, is there a role for CDK inhibitors in the context of #RB1 loss? Check out Dr. Albert Lin’s poster on targeting #CDK2 in this context! Tomorrow (Tuesday) at 2 pm UTSW Simmons Cancer Center

Impressive responses to #HER2-selective TKI #zongertinib in HER2mut #NSCLC, with ⬇️ diarrhea and rash ➡️what about other tumor types driven by HER2 mutations, like breast? ➡️what are the mechanisms of resistance? On target secondary HER2 mutations? #AACR25 nejm.org/doi/full/10.10…

Fresh out of press! 🧬🔬We are happy to share our latest work published in Diana Hoffman! shorturl.at/F4qnr A thread🧵 Please, Enjoy and share! #CancerResearch, #PrecisionOncology #CancerTherapeutics

Once again excellent work by Avantika Gupta showing that #APOBEC3 drives resistance causing mutations. #AACR25 10.1101/2024.04.29.591453 now in press Nature Genetics

Next up at #AACR25 #SABCS24 session: Brooke Felsheim UNC Lineberger defines prognostic features in #TNBC using DNA+RNA. #Bcells + #Tcells, RNA signature prognostic. #HRDscore not predictive nature.com/articles/s4152… npj Journals

If you’re leaving #AACR25 via O'Hare Intl. Airport, plan for at least 2 hours in traffic 😩 Note to self: next time, fly through midway!

Out now in Cancer Discovery and featured #AACR25, we show a combinatorial approach to overcome resistance to RAS(ON) inhibitor monotherapy in PDAC, where use of CDK4/6 inhibitor Palbociclib and CD40 agonist drives therapy-induced senescence & CD4 T cell-dependent tumor-immune equilibrium

Dr. Yuki Matsunaga presenting her award-winning poster! #proudmentor #AACR25 UTSW Simmons Cancer Center

Congrats to UTSW Simmons Cancer Center AACR grant awardees Qing Zhang Sangeetha Reddy!

#AACR25 swag for my kids! #sciencemom #Chicago AACR UTSW Simmons Cancer Center

I am thrilled to have joined NYU Langone Health Perlmutter Cancer Center at NYU Langone Health on May 1, 2025 as Assistant Professor and Director of Translational Research in Breast Cancer. Excited to launch the next chapter of our lab’s work in NYC and accelerate impact for patients with breast cancer.

The cutest new patients UT Southwestern Medical Center sprou.tt/14RmjPGFPlJ

Congrats to the UTSW PhD class of 2025! sprou.tt/1I7U23gMzEn