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Antibody binding reports spatial heterogeneities in cell membrane organization buff.ly/3MpMnHw (Nature Communications)

I’m delighted to share our work Alan Brown on the structures of axoneme, one of the largest macromolecular machine in nature! This is really a dream coming true! Now we have an atomic view of the core of cilia skeleton. nature.com/articles/s4158…

'Can we separate hallucinations and the antidepressant effects of psychedelics?' on Experiment experiment.com/projects/can-w… Fundamental research is important! Greg and Jack are looking to develop new antidepressants from psychedelics.

This work has found a home! nature.com/articles/s4146… Monash Biomedicine Discovery Institute EMBL Australia

Happy to announce that our efforts to establish elemental mapping for cryo-EM ❄️ by EELS 🌈 are now shared on bioRxiv: biorxiv.org/content/10.110… Congratulations to Olivia Pfeil-Gardiner and co-authors! But wait - Can we map elements in 3D? 🧵👇 1/6

LYTACs pioneered by Carolyn Bertozzi opened the door to degradation of cell surface and extracellular proteins through lysosomal targeting. Here, we introduce genetically-encoded LYTACs, or GELYTACs, which are (1) easier to produce by recombinant expression (LYTACs, antibody

This work was led by outstanding postdocs Kevin Chen, Vikas Tillu, Navin Gopaldass, Sudeshna Chowdhury, and with amazing assistance from Juanfang Ruan at the UNSW Microscopy unit. Kevin Chen Vikas Tillu Natalya Leneva Oleksiy Kovtun Nick Ariotti Institute for Molecular Bioscience UQ News. 2/n

Congratulations to our researchers who have been awarded NHMRC 2024 Investigator Grants to address health challenges. ◾ A/Prof Frederic Gachon (@GachonLab) ◾ Prof Glenn King (Glenn King) ◾ Dr Marina Naval Sanchez (Marina Naval) ◾ Dr Hana Starobova (Hana Starobova)

Our mini-review of the recent reports revealing the architecture of the Commander complex is online. s.gwdg.de/s6BN9g

Will it be the next #antibiotic? A lasting treatment for #ChronicPain? A new way to stop #cancer in its tracks or a novel insight into the #genome? Do your #PhD at IMB and join some of the world's best to see what you will discover. 🔍 Explore now: bit.ly/3VF2N4A

We are hiring! 2 #postdoc #positions in advanced infection models and in data-driven #virology tba on Sept 4th at tinyurl.com/2bdvs7yk Join an enthusiastic and international team of virologists Medizinische Uni in beautiful Tyrol. Join the club of those who #lovevirology

Thrilled to share progress on Ras isoform binders! Using AI-driven protein design, I’ve targeted the challenging, highly charged and disordered C-terminus of Ras. These de novo binders exceed antibody specificity and effectively disrupt Ras signaling. biorxiv.org/content/10.110…

I am thrilled to share that our manuscript on using LEA proteins to prevent air-water interface damage to fragile samples for cryo-EM is offically out! doi.org/10.1038/s41467…

Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/sc…

Precision in situ cryo-correlative light and electron microscopy of optogenetically-positioned organelles journals.biologists.com/jcs/article/do…

Our latest work on DPANN archaea is now published in the ISME Journal (pubmed.ncbi.nlm.nih.gov/39113594/). Using cryoET, we discovered an enormous attachment organelle in the DPANN cell envelope that forms a cytoplasmic bridge between the host and DPANN cells.

Thrilled to share our findings on NINJ1 autoinhibition, now online in nature. Big thanks to the amazing team Vishva Dixit Melissa Truong Matt Johnson Alexis Rohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)

Devastating, short-sighted and shamefully irresponsible announcement by UOW management today of 135 proposed sackings, including whole teaching departments such as history. All the while the VC is a partner in a consultancy firm reviewing the university’s operations. NTEU