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Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with Teresa Thurston and Magdalena Szczesna, with rach☔️ driving our side of the project using some amazing tools built by the Geurink lab.

Ubiquitination of proteins, LPS, lipids and sugars? Read our comment (with @komander_lab) on the size and complexity of the #ubiquitin system now in NatureStructMolBiol: "The ubiquitin system - Just how big is it?" rdcu.be/dyqzt.

Now out in Molecular Cell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉shorturl.at/jrsBG #cryoEM Max Planck Institute of Biochemistry (MPIB) UNLV College of Sciences St. Jude Research @DanielS20127197 rajan prabu (1/2)

🔬 Join us at EPFL's School of Life Sciences as a Staff Scientist Expert in Cryo-EM! Work with cutting-edge facilities, collaborate with top researchers, and drive groundbreaking discoveries in structural biology. Apply now: ch.indeed.com/viewjob?jk=b45… #ScienceJobs #CryoEM #EPFL

🎉 Exciting news! Our seminar series on non-canonical ubiquitylation is BACK! 🎉 Gary Kleiger presenting on April 15th, exploring ARIH1's non-canonical activity. Stay tuned for Ivan Ahel (Ivan Ahel Lab) & Bernhard Lechtenberg (Bernhard Lechtenberg)! #Ubiquitin #researchers

Genetically encoding negatively charged lysine PTMs succinylation/glutarylation and studying their funcional roles! Great team effort by first authors @ML_Jokisch and Maria Weyh! Congrats Maria Weyh @ML_Jokisch Max Fottner and Anh! 🥳🤩🙌👨‍🔬🧑‍🔬 Kathrin Lang nature.com/articles/s4155…

🚨Excited to share that our manuscript is now published in NatureStructMolBiol. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone-mediated multistep assembly pathway of the human 20S #proteasome. Max Planck Institute of Biochemistry (MPIB) @HarvardCellBio Aligning Science Across Parkinson’s nature.com/articles/s4159…

Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in Molecular Cell! ➡️cell.com/molecular-cell… Karthik Gottemukkala, D.Sherpa, Arno Alpi Schulman lab Max Planck Institute of Biochemistry (MPIB)

Alpi, Schulman, Mann and Murray labs decipher regulation of human NMNAT1 (NAD+ biosynthetic enzyme) by gigantic WDR26-CTLH E3 ligase complex! ❕cell.com/molecular-cell… #ubiquitin #E3ligase Karthik Varma Gottemukkala Jakub Chrustowicz D.Sherpa Arno Alpi Matthias Mann Lab Peter J Murray

Extremely grateful and honored to receive the Otto Hahn Medal from the Max Planck Society Max Planck Society . Thank you Brenda Schulman Max Planck Institute of Biochemistry (MPIB) , Arno Alpi , Jakub Chrustowicz , past and present GID team members and the Schulman Lab family for making this possible.

Branched #ubiquitin has important roles in cell signaling but are very challenging to study due to complexity & lack of tools. We tackle this challenge in our latest study NatureStructMolBiol developing a toolkit enabling discovery of molecular players and pathways rdcu.be/dM5nn

We are hiring! If you are interested in the role of ubiquitin in regulating proteostasis and innate immune signaling, please apply 👇 #ubiquitin #proteostasis #proteasome #autophagy #mitochondria #neurodegeneration jobs.ruhr-uni-bochum.de/jobposting/c96…

We are hiring! Two structural biology/biochemistry postdoc positions are available in our lab - come and join a lively Team in the thriving city of Oxford! Deadline 4th October 2024. Further details are here: my.corehr.com/pls/uoxrecruit…

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!! biorxiv.org/content/10.110…

Impressive #EMBOubiquitin24 in #Cavtat with more than 300 participants & active discussions at posters. Superb success- thx to the organisers @MerblYifat76992, Yogesh Kulathu, Joazeiro Lab, Polo Lab, EMBO Events 🙌👏🫶👍 The hotel and weather matched the quality of science 😊 ⁩

Excited to report our discovery of an important component of the oxidative stress response, the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. biorxiv.org/content/10.110…

Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust the electron transport chain, with many implications for ROS in development and disease. UC Berkeley Molecular Therapeutics Initiative cell.com/molecular-cell…

Excited about #Fungal pathogens and the interplay with the host? Fully funded PhD in our lab Institute for Regeneration and Repair ZJU-UoE Institute Edinburgh Infectious Diseases. Excellent team, including JP Lab Dr. Edward Wallace and teaching in China! Deadline 31st January. Please RT! biomedical-sciences.ed.ac.uk/postgraduate-s…

Congratulations to Arno Alpi and Peter Murray for the FEBS Letters Award 2025. 🥳 Peter J Murray Arno Alpi

Check out our latest review in Molecular Cell! We discuss how formaldehyde, a toxic metabolic by-product, threatens genome stability and disrupts cellular homeostasis. 👏Terrific job by the talented #MartaValverde Josep Carreras Leukaemia Research Institute (IJC) 📰👉authors.elsevier.com/a/1lDFm3vVUPVa… cell.com/molecular-cell…