Arooj Mian
@aroojmianmd
GI fellow @readinghosp | Board certified internist @AdventHealthCFL | Women in medicine 👩🏻⚕️
ID: 1593427259955757056
18-11-2022 02:14:08
88 Tweet
354 Followers
245 Following
Had a blast with my girl Hira Hanif at #IBD101 Great course for 1st year fellows 💯 #GITwitter
Have you registered for Scrubs & Heels #leadershipsummit2025? Register at scrubsandheels.com and share your Mindset4success Strongly encourage trainees to attend, expand their network and connect with mentors/friendtors #Findyourtribe 👩🏻⚕️💃🏻👠
Can’t wait to be surrounded by a room full of #womeninGI who inspire me (not only in GI, but also in fashion 👠) But most of all, can’t wait to be reunited with & support my girl Aimen Farooq for all her hard work in making sure #SNH25 is a hit! #Mindset4Success #SheLeads
💜#GITeam #CRSurgery Join us for a convo led by Stefan Holubar MD MS Aline Charabaty, MD, FACG, AGAF 🏁Stages to IPAA in UC - can we stop before the finish line? 🆓#CME👉🏽bit.ly/MNIBD24-25 🗳️Poll👇🏽, RT, share your 💬 & expertise with us Support by edu grants AbbVie JanssenUS Takeda
#MondayNightIBD 1/🔹Immune checkpoints like CTLA-4, PD-1,PD-L1 AND LAG-3 suppress T-cell activity -> cancer cells evade immune anti-tumor response 🔹IC inhibitors (ICI)➡️ Reactivation T-cell response to CA➡️ improved survival across many cancers. #MNIBD #Back2Basics #MedTwitter
#MondayNightIBD elizabeth buchbinder Jamie Chaft GREGORY W FISCHER, MD margaret barton-burke Myriam Chalabi Timothy Chan Keith Siau Arndt Vogel Ryan Nipp, MD, MPH, MBA, FASCO Carl Kay, MD 2/⚠️T cells activated by ICI can cross-react w normal tissue -> Autoimmune-like phenomena called immune-related adverse events (irAEs) 💩GI, skin, liver, lungs, & endocrine systems are most commonly affected ⌛️ Organ specific irAEs occur at different time from ICI initiation
#MondayNightIBD elizabeth buchbinder Jamie Chaft GREGORY W FISCHER, MD margaret barton-burke Myriam Chalabi Timothy Chan Keith Siau Arndt Vogel Ryan Nipp, MD, MPH, MBA, FASCO Carl Kay, MD Ugo Iroku MD Amir Ghaffari Amy Bugwadia, MS Gastrolegacy Muddasir Ayaz Sophie Restellini Mary Barbara Kerri Glassner Sang Hyoung Park Megan Lutz 3/It's important to recognize that ICI can cause diarrhea without colitis 🔹% ICI-diarrhea > %ICI-colitis ⚠️ Confirm colitis vs simple diarrhea to ❌Avoid over-use of steroids ❌Avoid missing colitis dx: ⚠️Earlier scope & treatment= better prognosis
#MondayNightIBD elizabeth buchbinder Jamie Chaft GREGORY W FISCHER, MD margaret barton-burke Myriam Chalabi Timothy Chan Keith Siau Arndt Vogel Ryan Nipp, MD, MPH, MBA, FASCO Carl Kay, MD Ugo Iroku MD Amir Ghaffari Amy Bugwadia, MS Gastrolegacy Muddasir Ayaz Sophie Restellini Mary Barbara Kerri Glassner Sang Hyoung Park Megan Lutz Jan Král Nabil Quraishi Rashid Lui 雷諾信 Javier A. Villafuerte Gálvez Harry Sokol Evan Lipson Deepak Gopal Ryan Smith Jean-Paul Achkar Ari Garber MD, EdD 4/ CTCAE grading of ICI-diarrhea & ICI-colitis severity: ⬆️in # of BM/day over baseline (or⬆️ostomy output) 🔹Abdo pain, blood in stool 🔹Fever, HE instability, 🏥, peritoneal signs
#MondayNightIBD elizabeth buchbinder Jamie Chaft GREGORY W FISCHER, MD margaret barton-burke Myriam Chalabi Timothy Chan Keith Siau Arndt Vogel Ryan Nipp, MD, MPH, MBA, FASCO Carl Kay, MD Ugo Iroku MD Amir Ghaffari Amy Bugwadia, MS Gastrolegacy Muddasir Ayaz Sophie Restellini Mary Barbara Kerri Glassner Sang Hyoung Park Megan Lutz Jan Král Nabil Quraishi Rashid Lui 雷諾信 Javier A. Villafuerte Gálvez Harry Sokol Evan Lipson Deepak Gopal Ryan Smith Jean-Paul Achkar Ari Garber MD, EdD Shrinivas Bishu Reezwana C, MD, FACG Tanvi Dhere,MD Waqqas Afif, MD Robert Battat MD Jami Kinnucan, MD, FACG, AGAF, FCCF Nisha Loganantharaj Seb Jeffrey McCurdy MD PhD Kajali Mishra 5/ ICI-induced enterocolitis: 🔹Incidence & interval between starting ICI & developing colitis vary by agent ⬆️risk w ⬆️ICI dose ⬆️risk & earlier onset w ICI combo vs monotherapy ⚠️ Can progress rapidly -> complications: perforation, toxic megacolon, Intra-abdominal abscess
#MondayNightIBD elizabeth buchbinder Jamie Chaft GREGORY W FISCHER, MD margaret barton-burke Myriam Chalabi Timothy Chan Keith Siau Arndt Vogel Ryan Nipp, MD, MPH, MBA, FASCO Carl Kay, MD Ugo Iroku MD Amir Ghaffari Amy Bugwadia, MS Gastrolegacy Muddasir Ayaz Sophie Restellini Mary Barbara Kerri Glassner Sang Hyoung Park Megan Lutz Jan Král Nabil Quraishi Rashid Lui 雷諾信 Javier A. Villafuerte Gálvez Harry Sokol Evan Lipson Deepak Gopal Ryan Smith Jean-Paul Achkar Ari Garber MD, EdD Shrinivas Bishu Reezwana C, MD, FACG Tanvi Dhere,MD Waqqas Afif, MD Robert Battat MD Jami Kinnucan, MD, FACG, AGAF, FCCF Nisha Loganantharaj Seb Jeffrey McCurdy MD PhD Kajali Mishra Vincent Cheung Andrew Protheroe PaulKlenermanLab 𝚂𝚊𝚛𝚊𝚑 𝚂𝚊𝚜𝚜𝚘𝚗 Kathryn Bollin Pauline Funchain Jarushka Naidoo Kelly (Faltus) Brassil, PhD, RN Tauseef Ali MD, FACG AGAF FACP 6/ Initial work-up for suspected ICI colitis includes: 🧪 CBC, CMP, CRP 🦠 Stool studies: C. diff, culture, Giardia 🧫 Fecal calprotectin/lactoferrin 🔦Scope: at least Flex sig, prefer EGD/CLN w bx 🔍 TB test, hepatitis B screen before starting biologic
#MondayNightIBD elizabeth buchbinder Jamie Chaft GREGORY W FISCHER, MD margaret barton-burke Myriam Chalabi Timothy Chan Keith Siau Arndt Vogel Ryan Nipp, MD, MPH, MBA, FASCO Carl Kay, MD Ugo Iroku MD Amir Ghaffari Amy Bugwadia, MS Gastrolegacy Muddasir Ayaz Sophie Restellini Mary Barbara Kerri Glassner Sang Hyoung Park Megan Lutz Jan Král Nabil Quraishi Rashid Lui 雷諾信 Javier A. Villafuerte Gálvez Harry Sokol Evan Lipson Deepak Gopal Ryan Smith Jean-Paul Achkar Ari Garber MD, EdD Shrinivas Bishu Reezwana C, MD, FACG Tanvi Dhere,MD Waqqas Afif, MD Robert Battat MD Jami Kinnucan, MD, FACG, AGAF, FCCF Nisha Loganantharaj Seb Jeffrey McCurdy MD PhD Kajali Mishra Vincent Cheung Andrew Protheroe PaulKlenermanLab 𝚂𝚊𝚛𝚊𝚑 𝚂𝚊𝚜𝚜𝚘𝚗 Kathryn Bollin Pauline Funchain Jarushka Naidoo Kelly (Faltus) Brassil, PhD, RN Tauseef Ali MD, FACG AGAF FACP 7/ Endoscopic🔦findings in ICI colitis range from normal to IBD-like 🔬Histo: destructive pattern w crypt/epithelial apoptosis; acute/chronic inflam, cryptitis & crypt architecture distortion 📌Can mimic microscopic colitis or celiac ⚠️Always biopsy—even if mucosa looks normal
