Artem Isaev (@artem_isaev_) 's Twitter Profile
Artem Isaev

@artem_isaev_

ID: 1486638120531636230

calendar_today27-01-2022 09:52:10

49 Tweet

209 Followers

107 Following

Artem Isaev (@artem_isaev_) 's Twitter Profile Photo

We performed a dedicated search of anti-CRISPR proteins targeting the model E. coli Type IE CRISPR-Cas system and revealed AcrIE9 as a potent inhibitor and the most widespread anti-CRISPR protein in enteric bacteria. biorxiv.org/content/10.110…

bioRxiv Microbiology (@biorxiv_micrbio) 's Twitter Profile Photo

Design and development of lysyl tRNA synthetase inhibitors, for the treatment of tuberculosis biorxiv.org/content/10.110… #biorxiv_micrbio

Biology+AI Daily (@biologyaidaily) 's Twitter Profile Photo

Multiobjective learning and design of bacteriophage specificity ļ¼‘ļ¼ŽThis study presents a landmark demonstration of multiobjective machine learning to design bacteriophages with tunable infectivity, precise host specificity, and broad generality, optimizing over 26 complex tasks

Multiobjective learning and design of bacteriophage specificity

ļ¼‘ļ¼ŽThis study presents a landmark demonstration of multiobjective machine learning to design bacteriophages with tunable infectivity, precise host specificity, and broad generality, optimizing over 26 complex tasks
bioRxiv Microbiology (@biorxiv_micrbio) 's Twitter Profile Photo

Elucidating the mechanisms of action and evolutionary history of phage anti-defence proteins biorxiv.org/content/10.110… #biorxiv_micrbio

Sternberg Lab (@sternberglab) 's Twitter Profile Photo

New pre-print(s) from the Sternberg Lab in collaboration with Leifu Chang! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493

New pre-print(s) from the Sternberg Lab in collaboration with <a href="/LeifuChangLab/">Leifu Chang</a>! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs.

Full story here: tinyurl.com/mr3fd493
Leifu Chang (@leifuchanglab) 's Twitter Profile Photo

Our new preprint is live! doi.org/10.1101/2025.0… In collaboration with Sternberg Lab, we determined the cryo-EM structure of a dCas12f-σE-RNAP complex from F. taeanensis, revealing an RNA-guided transcription mechanism that bypasses canonical promoter motifs.

Tim Blower (@blowerlab) 's Twitter Profile Photo

Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and Darren Smith. Nucleic Acids Res New England Biolabs Durham BioSciences academic.oup.com/nar/article/53…

Rafal Mostowy (@rafalmostowy) 's Twitter Profile Photo

What determines who a phage can infect? We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort. šŸ‘‡ A thread!

What determines who a phage can infect?

We tackled this question for temperate phages of Klebsiella — a bacterial pathogen — using a genome-wide association study (GWAS) and a massive protein testing effort.

šŸ‘‡ A thread!
Kazuaki Amikura (@amikura1986) 's Twitter Profile Photo

Our new preprint is now available! We found a new Group I intron insertion site in tRNA genes of Patescibacteria. These tRNAs were missed by standard tRNA annotation tools. #microbiology #tRNA #Patescibacteria biorxiv.org/content/10.110…

Wendy Figueroa (@wfigueroac3) 's Twitter Profile Photo

So happy to share my work JosĆ© R PenadĆ©s lab 🤩 We investigated the efficiency of HGT mechanisms in S. aureus🧬, finding that LT is the most efficient one, and that strains defective in immune systemsšŸ›”ļøact as gateways for inter-clonal complex HGTšŸ”€ biorxiv.org/content/10.110…

bioRxiv Microbiology (@biorxiv_micrbio) 's Twitter Profile Photo

Nuclease-NTPase systems use shared molecular features to controlbacterial anti-phage defense biorxiv.org/content/10.110… #biorxiv_micrbio

Nitzan Tal (@nitzan_t) 's Twitter Profile Photo

šŸ“¢Preprint out! Excited to share my final work from the @Soreklab! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!

šŸ“¢Preprint out!
Excited to share my final work from the @Soreklab!

We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.

Found 3 new families targeting immune signaling!
Tim Blower (@blowerlab) 's Twitter Profile Photo

RptR is a new addition to the growing collection of phage defence-associated transcriptional regulators. Congrats to YuGeng Zhang Tang Lab, Oxford Marion Schuller Ivan Ahel Lab and thank you, it was a pleasure to help out the study! New England Biolabs. academic.oup.com/nar/article/53…

Vatsan Raman (@vatsanraman) 's Twitter Profile Photo

Excited to share our new work—PhageMaP, a high-throughput platform for genome-wide knockout screening in diverse phages across multiple hosts. PhageMap reveals essential, non-essential and conditionally-essential genes, interactors with host anti-phage defenses & enables rational

Excited to share our new work—PhageMaP, a high-throughput platform for genome-wide knockout screening in diverse phages across multiple hosts. PhageMap reveals essential, non-essential and conditionally-essential genes, interactors with host anti-phage defenses &amp; enables rational
bioRxiv Microbiology (@biorxiv_micrbio) 's Twitter Profile Photo

A Phage Ejectosome Protein Moonlights to Inhibit CBASS Anti-Viral Defense System biorxiv.org/content/10.110… #biorxiv_micrbio