
Artem Isaev
@artem_isaev_
ID: 1486638120531636230
27-01-2022 09:52:10
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209 Followers
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New pre-print(s) from the Sternberg Lab in collaboration with Leifu Chang! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493


Our new preprint is live! doi.org/10.1101/2025.0⦠In collaboration with Sternberg Lab, we determined the cryo-EM structure of a dCas12f-ĻE-RNAP complex from F. taeanensis, revealing an RNA-guided transcription mechanism that bypasses canonical promoter motifs.


Our review on the versatile roles of phage-encoded tRNAs is out. Great work Daan F van den Berg authors.elsevier.com/a/1lHYB,L%7EyCā¦

Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and Darren Smith. Nucleic Acids Res New England Biolabs Durham BioSciences academic.oup.com/nar/article/53ā¦




So happy to share my work JosĆ© R PenadĆ©s lab 𤩠We investigated the efficiency of HGT mechanisms in S. aureusš§¬, finding that LT is the most efficient one, and that strains defective in immune systemsš”ļøact as gateways for inter-clonal complex HGTš biorxiv.org/content/10.110ā¦




RptR is a new addition to the growing collection of phage defence-associated transcriptional regulators. Congrats to YuGeng Zhang Tang Lab, Oxford Marion Schuller Ivan Ahel Lab and thank you, it was a pleasure to help out the study! New England Biolabs. academic.oup.com/nar/article/53ā¦

