Paper out Ecography lead-authored by Yanjie Xu 🌍🐧 on the impact of #climatechange on the threat of bird- and bat-associated pathogens across Europe. First results of DISEASES-ON-WINGS #CLIHE Suomen Akatemia | Research Council of Finland project with @thomaslilley77 @AksuLehikoinen onlinelibrary.wiley.com/doi/full/10.11…

Paper out on the development of DNA nanoflower-based #nanoparticle to treat #MRSA #biofilm #keratitis. Glad to be involved in this study led by Hongbo Zhang and colleagues at Åbo Akademi University and abroad in China. Turun yliopisto - University of Turku onlinelibrary.wiley.com/doi/10.1002/sm…

Closing seminar of #CLIHE Climate Change and Health Academy Programme 2020-2023 Suomen Akatemia | Research Council of Finland. Here, I summarize our Europe-wide data with Luomus PIs @thomaslilley77 @AksuLehikoinen on what bacterial #pathogens with what #virulence and #AMR factors are found in wild-life.

Paper out American Genetic Association. This was a laborious task to isolate and immortalize cells from the northern bat for our bacterial evolution projects. Here, the cells were used by @thomaslilley77 @BatLabFinland to determine the northern bat reference genome. doi.org/10.1093/jhered…

Paper out Toxins MDPI . Host cell chaperons fold and activate bacterial toxins. Glad to contribute to this study led by Katharina Ernst Universität Ulm identifying TRiC/CCT chaperon inhibitor neutralizing pertussis toxin. mdpi.com/2072-6651/16/1…

🌍🐧🦇🤗 Our new paper One Earth: Slow-lived birds and bats carry higher pathogen loads doi.org/10.1016/j.onee… Luomus HiLIFE_Helsinki Suomen Akatemia | Research Council of Finland European Bird Census Council @AksuLehikoinen @thomaslilley77 Arto Pulliainen

May 24th, our Moona Sakari defended her PhD thesis on bacterial exotoxins -utupub.fi/handle/10024/1… Many thanks to our funders, collaborators in Finland and abroad and to opponent Christian Hedberg from Umeå University for such an inspiring discussion. Turun yliopisto - University of Turku

The lab welcomes our new member, undergraduate researcher Ellen Skrabb (BSc) from Åbo Akademi University. She works on functional characterization of new bacterial #exotoxin variants identified with our #bioinformatics tool on environmental shotgun #metagenome data. Turun yliopisto - University of Turku

Paper out FASEB doi.org/10.1096/fj.202… We report new molecular insights on the regulation of gut inflammatory response by using mouse models of #Salmonella infection and inflammatory bowel disease (IBD), and samples of an #IBD patient cohort. #ADPribosylation #PARP14

The lab welcomes our new member, Ilona Nieminen (BSc). She optimizes our new yet-to-be-published drug screening assay, in collab. with Kari Kopra (University of Turku, Dept. of Chemistry) and aims to identify new bacterial exotoxin-neutralizing compounds. #AMR

Paper out Journal of Biological Chemistry of a novel pertussis toxin neutralizing function for the human acute phase protein alpha1-antitrypsin with our colleagues from Universität Ulm and elsewhere in Germany and USA. doi.org/10.1016/j.jbc.…

paper out on new research tools Journal of Biological Chemistry We describe an ADP-ribosyltransferase-based biocatalytic process to produce new kinds of non-hydrolyzable NAD+ analogs. doi.org/10.1016/j.jbc.…

Paper out. We report characteristics of the fecal microbiota in common migratory birds and bats. The data implies that these vertebrates may contribute to the transmission of enteric bacterial pathogens across the European continent. Suomen Akatemia | Research Council of Finland journals.asm.org/doi/10.1128/sp…

The lab welcomes our new member, undergraduate researcher, biology student Amanda Barsk. She aims to understand what happens in bacterial infections when exotoxins recognize their host cell surface protein receptors, via characterization of the receptor protein interactomes.

Preprint out. Using a mouse model of Salmonella Typhimurium infection, also involving single cell RNA-Seq data analysis, we report new molecular insights on the regulation of gut inflammatory response. biorxiv.org/content/10.110…

TCML attends ETOX2025 close to Bilbao at Arantzazu, Basque Country, Spain - biannual global meeting venue of the experts of bacterial protein toxicology. etox-meetings.org