This is a monumental paper from Arvind. Not only did work out in his PhD how the classic model for allostery haemoglobin evolved. Now he designed allosteric proteins entirely from scratch. It think that's an awesome arc. nature.com/articles/s4158…

Super excited to share that our work on de novo design of allosteric proteins is now out in nature!👩🏽‍🔬 Huge thank you to Arvind S Pillai for his amazing mentorship and letting me be a part of this! nature.com/articles/s4158…

Awesome paper in nature! Arvind S Pillai achieved theoretically perfect ligand binding cooperativity with a hill coefficient of ~4 (hemoglobin is ~2.8 by comparison). Congrats Arvind, Abbas, Florian Praetorius and team, truly an honor to help with this work: nature.com/articles/s4158…

Love this article by Charlotte Schubert GeekWire on what we're trying to do here in #Seattle at XairaTherapeutics Justas Dauparas Nate Bennett geekwire.com/2024/inside-th…

Brooke is the most talented,productive and empathetic scientist I personally know- if you are a young marine ecologist looking to join a group with a bright future and excellent mentorship, you should strongly consider joining to the Weigel lab at Hopkins Marine Station Stanford University Stanford University !

We are pleased to announce our latest work, in which we report the characterization of a new monoamine oxidase family member in vertebrates (MAO C). We collaborated with PhD students, postdocs, research assistants, and colleagues 😊 Universidad San Sebastián biorxiv.org/content/10.110…

A reminder that proteins are highly dynamic molecules. ◼ We have made progress in measuring & predicting static protein structures, but the dynamics that animate life remain challenging to measure & model.

David didn’t just launch a field that's transforming science and soon, our lives—he did it while being an incredible mentor and a caring human. His dedication to his lab and students is just as worth celebrating. Cograts to David and to us at the Institute for Protein Design!

#CrispyShifty proteins mentioned - highlight of the announcement for me 😁 Arvind S Pillai Florian Praetorius

Read this amazing work from Adam & co on designing complexes whose kinetics of assembly and disassembly can be allosterically controlled with remarkable precision!

New paper from us and SYBORG by Luca Schulz : embopress.org/doi/full/10.10…. It's about the evolution of essentiality. This question has fascinated me for a long time: How does a component that was previously unnecessary for some function become essential for it?

Thrilled to see our work on protein nanocage design published in nature! These nanocages have exciting potential applications in drug delivery and vaccines. nature.com/articles/s4158… Thank you to Sangmin Lee for the opportunity to contribute to this amazing project!

Excited and proud to have this paper published with Nature Communications today! Great project led by Juan L. Mendoza at UChicago Pritzker School of Molecular Engineering and HHMI. Excited for the future of the field - stay tuned for a full breakdown and walkthrough of our results! nature.com/articles/s4146…

My first first-author paper is out! It was an amazing collaborative effort with a lot of amazing people including Arvind S Pillai and JoeThornton. Please read if you like things involving evolution and biochemistry. pnas.org/doi/10.1073/pn…

Read this awesome paper from Carlos Cortez about the biophysical and genetic mechanisms by which proteins evolve to assemble into highly specific assemblies of distinct molecular units. Proud to have contributed!

Happy National Draw a #Dinosaur Day! ✏️🦖 These masterpieces(?) were created during the 2023 National Fossil Day Livestream by Kallie Moore, Michelle Barboza-Ramirez, Blake de Pastino, and Gabriel Santos. Tag us in your dino drawings!

Small proteins can be more complex than they look! We know proteins fluctuate between different conformations- but how much? How does it vary protein to protein? Can highly stable domains have low stability segments? Állan Ferrari experimentally tested >5,000 domains to find out!

We’re proud to welcome two bold scientific minds to the Institute! Arvind Pillai, PhD, joins as Assistant Investigator exploring protein #evolution & design. Friederike Benning, PhD, joins as Stowers Fellow studying membrane complexity in #bacteria. More: bit.ly/3SCZQiM

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: biorxiv.org/content/10.110…