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Very excited to share our paper just out in Plos Genetics showing pyruvate import ameliorates fly models of dementia! Congratulations to Dongwei and Alec first authors! And thanks to Alzheimer's Research UK for funding! #PLOSGenetics: dx.plos.org/10.1371/journa…

.Adrian Isaacs shares his optimism for new dementia treatments. He & his team of researchers UK Dementia Research Institute are studying the underlying causes of dementia that will one day lead to new treatments for people with diseases like Alzheimer’s. His vital work will help us change the ending.

Our own Dr Niccoli recently talked to Alzheimer's Research UK about Frontotemporal Dementia, a disease we research in the lab. Read the blog here: tinyurl.com/msaxeest for a deep dive into this rare type of dementia. IHAatUCL (no longer posting) #FTD #FrontotemporalDementia

Excited to share the work of our postdoc Duxin showing a key role of Xbp1 in modulating neuronal vulnerability to C9orf72 repeat expansion toxicity. Thanks to our collaborators Evan Udine Adrian Isaacs and Tammaryn Lashley biorxiv.org/content/10.110…

Last week I successfully defended my PhD work in the labs of Adrian Isaacs UK Dementia Research Institute and Linda Partridge IHAatUCL (no longer posting) UCL Biosciences. Thank you to my examiners @JepsonlabU and Kevin Talbot for an enjoyable viva discussion! #PhDone

Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by Ashling Giblin and Alex Cammack biorxiv.org/cgi/content/sh… 1/9

Delighted to share our preprint describing neuronal polyunsaturated fatty acids as protective in FTD/ALS. A fantastic collaboration with @MartinGiera @rikvanderkant Tammaryn Lashley. Massive thank you to Research at ARUK for funding my PhD and @CZI for the support!

We have a new LifeArc funded post-doc position to follow up this work, applications close Feb 6th: ucl.ac.uk/work-at-ucl/se…

I'm finally hiring to the newly-established Fowler Lab in Oxford! 👩‍🔬 Drop me a line if you're interested in EVs, tau, proteomics, and super-resolution microscopy! 2-yr RA (corehr.com) and 3-yr Postdoc (corehr.com) positions available! #phd #science #jobs

Well this was unexpected! We found that TDP-43 forms heteromeric amyloid filaments with a second protein, annexin A11, in the neurodegenerative disease FTLD-TDP Type C. Read the preprint here: biorxiv.org/content/10.110…

Very excited to see our manuscript on the Neurolipid Atlas online @S_Koppes_Hertog @vanderkantLab @Martingiera! Big thanks to all collaborators! biorxiv.org/content/10.110… neurolipidatlas.nl A thread:

Our take on striking new findings from the Ryskeldi-Falcon lab on hybrid protein filaments in disease. I suspect this will be the tip of the iceberg, and there are additional implications for normal cell biology from their study. nature.com/articles/d4158…

Thank you UK Dementia Research Institute for this recognition!

Reduced phospholipid species containing polyunsaturated fatty acids (PUFAs) in C9 #ALS/FTD Drosophila, iPS cell-derived neurons, and postmortem #FTD brain tissue; increasing PUFA levels in neurons is protective in fly and cellular models nature.com/articles/s4159…

Great to see this news and views piece by Sandeep Dubey and Hugo Bellen of our recently published work! Alex Cammack Adrian Isaacs Lab UK Dementia Research Institute IHAatUCL (no longer posting) nature.com/articles/s4159…

🚨MRC Research Fellow Vacancy: Studying microglial ageing utilising iPSC-based cell biology, screening, biochemistry, genomics, imaging & bioinformatics Dr Dervis Salih, UK DRI at UCL 🗓️ Closing 26 June 👉 ucl.ac.uk/work-at-ucl/se…

Postdocs invited to apply to join an exciting project involving kinome-wide CRISPR screening in iPSC-derived motor neurons co-cultured with microglia to uncover novel targets for C9ORF72 motor neuron disease.  #MND #ALS #CRISPR #neuron #postdoc Visit: shorturl.at/Do9yU

Triglycerides are an important fuel reserve for synapse function in the brain go.nature.com/4nvjk7k