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Jacek Majewski, Nada Jabado & colleagues find that H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. McGill Genome McGill Human Genetics @McGillPeds go.nature.com/2L4i5xR

Jabado & co. find H3K27M mutations in pediatric high grade glioma (HGG) lead to pervasive gain of H3K27ac across the genome, including in ERVs, which primes them for activation by epigenetic therapies, revealing a therapeutic vulnerability in H3K27M HGG. cell.com/cancer-cell/fu…

Online @nature The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape go.nature.com/2lxS3qg

H3K27M in Gliomas Causes a One-step Decrease in H3K27 Methylation and Reduced Spreading Within the Constraints of H3K36 Methylation bit.ly/2UPXAa7

🔥DON’T MISS Nature Cancer - “Structural variants shape driver combinations and outcomes in pediatric high-grade glioma” by #FrankDubois Keith Ligon #RameenBeroukhim #PratitiBandopadhaya & Co. #glioma Find it here👇 rdcu.be/cQ0xt go.nature.com/3ImhOjF

💫 PUBLISHED TODAY Nature Genetics 📰 K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas 🧑🏽‍🤝‍🧑🏻 Claudia Kleinman Nada Jabado, and team 👇🏿 nature.com/articles/s4158…