Fionnuala Ní Áinle annmarieo World Thrombosis Day Thrombosis Ireland Maeve Crowley Barry Kevane Tomás Breslin Mike Watts HRB-TMRN savv That’s true! We wish we could take you on for HYPATIA too HYPATIAtrial Professor Beverley Hunt OBE (also on BlueSky) Saskia Middeldorp

Great to be part of this living ⁦World Health Organization (WHO)⁩ guideline on the utility of hydroxychloroquine to prevent #covid-19 Despite all the early hype, after reviewing all the evidence:- “We recommend against administering hydroxychloroquine to prevent covid-19” pubmed.ncbi.nlm.nih.gov/33649077/

Hurrahs welcome to AddenbrookesHospital being a site for HYPATIA! Lovely to have Willthomas & his team on board - thank you for your efficiency & enthusiasm 😄

Best start of the w/e: confirmation of one more patient enrolled into our RCT #HYPATIA HYPATIAtrial! This study will answer the q wether HCQ improves pregnancy outcomes in pregnant women with aPL #pregnancyinrheumaticdisease #APS Professor Beverley Hunt OBE (also on BlueSky) Saskia Middeldorp Willthomas Andrew Doyle

Over the moon! Our fantastic team at Nuffield Dept of Women's & Reproductive Health have recruited their first patient into our multi centre RCT HYPATIAtrial HYPATIA! 💫 Thank you all for your help! Next is Europe! Andrew Doyle Professor Beverley Hunt OBE (also on BlueSky) Willthomas Savino Sciascia Saskia Middeldorp #neverGiveUp #HCQinAPS

Laura Andreoli Alí Duarte, MD HYPATIAtrial We are working around the clock to make the HYPATIAtrial happen! Patient recruitment is ongoing thanks to amazing teams at St Thomas’, Cambridge, Oxford, Royal Free LDN soon Univ College London, Liverpool and Europe 🇪🇺🇩🇰🇮🇹🇳🇱Professor Beverley Hunt OBE (also on BlueSky) Andrew Doyle Willthomas Savino Sciascia

This made our day: opening my inbox, finding a HYPATIA HYPATIAtrial randomisation email from our amazing Cambridge team Willthomas! You are fantastic! #APS Professor Beverley Hunt OBE (also on BlueSky) Andrew Doyle Savino Sciascia #hydroxychloroquineInPregnancy

New article: Women with 1st venous #thrombosis #VTE are at risk of recurrence during #pregnancy De Moreuil Francis Couturaud et al @CHRU_Brest show high VTE recurrence in postpartum despite thromboprophylaxis. Maternal obesity is risk factor for VTE recurrence. bit.ly/3I3FoQU

Favourite emails! #OneMorePatientRecruit #HCQinAPS The HYPATIA study HYPATIAtrial will answer if HCQ improves pregnancy outcomes in pregnant women with aPL! Thank you GSTT team & thank you to all our patients! 🚀📈 Professor Beverley Hunt OBE (also on BlueSky) Savino Sciascia Saskia Middeldorp Willthomas Andrew Doyle

This team effort deserves another tweet: ladies & gentleman, HYPATIAtrial sponsor green light to open recruitment achieved. Welcome UCLH 🙌🏻#HCQinPregnancy #APS Professor Beverley Hunt OBE (also on BlueSky) Andrew Doyle APS_ACTION ISTH

Thank you Novo Nordisk Foundation for believing in me #EmergingInvestigator. Your support for HYPATIAtrial will allow our amazing team to complete the HYPATIA study! We are fighting to start in Denmark,Italy &the Netherlands! Professor Beverley Hunt OBE (also on BlueSky) Savino Sciascia Saskia Middeldorp #HCQinPregnancy #APS

This is a wonderful start to HYPATIAtrial opening up in Denmark!!

This is phenomenal! Running HYPATIAtrial has been such a struggle through #Brexit then #COVID19 This is the boost we need to open in Europe & finish this trial. Karen Schreiber has been truly outstanding in raising support 👏👏👏👏👏👏👏

#ICAPA2022 🇦🇷 Prof Karen Schreiber 🇩🇰Karen Schreiber discusses the use of #HydroxyChloroquine in #pregnancy with #antiphospholipidantibodies Looking forward to the results of #clinicaltrials 📊 #HYPATIA actively recruiting #APSmatters HYPATIAtrial Professor Beverley Hunt OBE (also on BlueSky) Savino Sciascia

How difficult it has been to run HYPATIA!

Our retrospective review of the use of hydroxychloroquine in 521 pregnancies, adds to the data showing no evidence of ⬆️ rates of fetal abnormalities when 200-400mgs HCG daily are used in pregnancy ⁦Karen Schreiber⁩ ⁦HYPATIAtrial⁩ academic.oup.com/rheumatology/a…

🚨: We held the 1st European HYPATIA study ⁦HYPATIAtrial⁩ site initiation visit in Copenhagen today! What a feeling! We are fighting to complete the #RCT of HCQ in pregnant women with aPL/APS 🙏🙌🏻⁦@Christine_ga_⁩ ⁦Professor Beverley Hunt OBE (also on BlueSky)⁩ ⁦Savino Sciascia⁩ 🇩🇰🇬🇧🇪🇺🌍

Autoimmune diseases and adverse #pregnancy🤰 outcomes: an umbrella review - The Lancet thelancet.com/journals/lance…

🥁We have written history today: We have included the first patient into the HYPATIAtrial #HYPATIA after moving sponsors of our ongoing #pregnancy RCT from the UK to the EU! Thank you team GSTT for the extraordinary work! 🥇🙌🏻 Professor Beverley Hunt OBE (also on BlueSky) Andrew Doyle What mountains of bureaucracy! 🏔️

What would be the most cost effective & acceptable RCT to assess thromboprophylaxis in pregnancy/ puerperium? - using decision analysis & qualitative studies of women & healthcare professionals - we found a RCT in obese postpartum women would be most valueable & acceptable