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Incredible story highlighting the biochemical innovations hiding in phages genomes and revealed by the study of phage-bacteria interactions.

Our NAD-reconstitution story is finally published in nature rdcu.be/dU5AQ Thank you to all co-authors, especially to hadarsamra, @FrancoisRousset, Elena Loseva, Erez Tzvi Yirmiya, Adi Millman, and everybody in the Sorek Lab for their help and support.

On the cover: mechanism of bacterial antiphage systems encoding reverse transcriptases , a beautiful exception to the central dogma. Congrats to the authors for these 2 wonderful studies. Much more incredible molecular biology to uncover in the hundreds of antiphage systems!

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Yasmine Belkaid : "Couper encore plus le budget de la recherche, c'est irresponsable". À l'occasion du #Pasteurdon", la directrice générale de l'Institut Pasteur était l'invitée de Léa Salamé et Nicolas Demorand sur France Inter. Entretien intégral radiofrance.fr/franceinter/po…

Meet The Shielded Plasmid🛡️🧬 Our new nature paper reveals how plasmids outsmart bacterial defenses during conjugation. It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency🧵(1/7) nature.com/articles/s4158…

Fellow microbial immunity, mobile elements, and plasmid enthusiasts: the paper of our wonderful Bruria Samuel on anti-defense genes in plasmids is now published in nature!!! Check out her thread below for highlights of our new results. 1/2

🦠🧬Our paper is live Cell: Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex authors.elsevier.com/sd/article/S00… Through structural, genetic and microbiological approaches, we show that Hachiman degrades DNA… by sensing low integrity DNA.

I am excited to share our work "Systematic discovery of antibacterial and antifungal bacterial toxins" that is published in Nature Microbiology nature.com/articles/s4156…

We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & Ilya Osterman

Did you know that bacteria remember their past for many generations? In this new preprint from us (Alexis Villani and Senen Mendoza) and Banin lab (Esther Shmidov ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…

Absolutely thrilled to share our new study, co-led by Puja Majumder and myself, now online in Cell! Here, we characterize a CRISPR-associated adenosine deaminase, Cad1. Incredibly grateful for @MarraffiniLab making it possible. Synopsis below: cell.com/cell/fulltext/…

🚨 New preprint alert! 🚨 We're excited to share our latest work: "Towards a complete phage tail fiber structure atlas" 🦠🔬 of first author Victor Klein-Sousa We developed #RBPseg for segmenting and merging phage tail fibers using structural prediction tools. tinyurl.com/58cn2ew7

Can i apply? This really sounds like an incredible opportunity.

OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information, by Aude Bernheim Hugo Vaysset MDMLab @iame_center Bacteriophage Lab Institut Pasteur nature.com/articles/s4156…

Woohoo, the Aude Bernheim lab is 🔥 Congrats!!

Super important! Receptors matter!

Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta Chandni Bhickta nicolas chiaruttini & in co. with @burnsajohn is finally out nature . Link⏩: nature.com/articles/s4158… Preprint⏩: biorxiv.org/content/10.110… 1/5)

🌟👏 Félicitations à Aude Bernheim Aude Bernheim, lauréate du Prix Irène Joliot-Curie dans la catégorie « Jeune femme scientifique » pour ses travaux sur l'immunité bactérienne et son rôle dans la défense antivirale et l'immunité humaine.