A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones: nature.com/articles/s4146…

🚨MRC Research Fellow Vacancy: Studying microglial ageing utilising iPSC-based cell biology, screening, biochemistry, genomics, imaging & bioinformatics Dr Dervis Salih, UK DRI at UCL 🗓️ Closing 26 June 👉 ucl.ac.uk/work-at-ucl/se…

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Conformational plasticity of a BiP–GRP94 chaperone complex: nature.com/articles/s4159…

How do cells clean up misfolded proteins when they divide? This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved. elifesciences.org/articles/96675…

ALS-associated RNA-binding proteins promote UNC13A transcription through REST downregulation | The EMBO Journal embopress.org/doi/full/10.10…

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF biorxiv.org/content/10.1... and MANF before nature.com/articles/s41... biorxiv.org/content/10.110…

Militsin, Palty et al. reveal novel crosstalk btwn STIM proteins & IP3Rs, whereby STIM activation alters the spatial pattern of IP3R-mediated Ca2+ release, shifting it from a promigratory localized signal to a diffuse, migration-suppressing signal hubs.ly/Q03z58_80

Short explanation of the physics Nobel Prize 2025 In classical mechanics you can know where a particle is and its momentum at the same time. In Quantum mechanics you can't. All information is in the wavefunction. Even if a particle is trapped, part of the wavefunction.. 🧵1/7

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️ #Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv biorxiv.org/content/10.110…

UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation | Nature Communications nature.com/articles/s4146…

Discovery of a tau-aggregate clearing compound that covalently targets P4HB: Cell Chemical Biology cell.com/cell-chemical-…

Delighted to see this out in Neuron!!! Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS cell.com/neuron/fulltex…

Glia inflammation and cell death pathways drive disease progression in preclinical and early AD embopress.org/doi/full/10.10…

1.🧠 Excited to share our new paper in Nature Cell Biology led by Rabia Khawaja : “Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome” nature.com/articles/s4155…

In a paper just published in Nature Medicine, we characterised the largest cohort of people with loss-of-function mutations in the Melanocortin 4 receptor (MC4R) gene. doi.org/10.1038/s41591… (1/6)

Huge congratulations to UK DRI Founding Director Prof Bart De Strooper who has been awarded an Honorary CBE for his contributions to dementia research! 👏 Read more👉 buff.ly/xhKD5Aj

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair biorxiv.org/content/10.110…