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The first episode of The Baker Lab Podcast is live. Meet Mohamad Abedi, who went from being a Palestinian refugee to a postdoctoral researcher. His journey proves that science can be a creative and transformative process. Apple: podcasts.apple.com/us/podcast/the… Spotify: open.spotify.com/show/32pWWpKzO…

We updated our EvoBind paper with the cyclic binder results: it turns out we can design cyclic peptide binders in a single shot with sub nM affinity only from sequence information (75% success rate). Protein binder design is getting very good. Stay tuned. biorxiv.org/content/10.110…

Ancestral enzymes for the win! 🥇 Congratulations to Chad Ye Wang and Azam Hussain for this amazing work! Go ancestors go! #Biocat #ASR #GoBlue

TED: The Encyclopedia of Domains now published in Science Magazine discovering and annotating 314 MILLION protein domains in the AlphaFold database. joint work of @CATH_Gene3D and PSIPRED here at UCL.

hey i'm really sorry to keep hyping our own product but you really should get chatgpt plus and install the chrome extension for search i am cheerfully the first to admit when we ship something that isn't very good, but this time it's...really good

I am thrilled to start today Caltech and looking forward to the exciting science ahead.

nature.com/collections/ij…

Now in nature, AI Microsoft Research that simulates proteins with more than 10,000 atoms with quantum accuracy, orders of magnitude faster than ever before. AI2BMD's results match those of wet-lab experiments, enabling new biomedical research advances. nature.com/articles/s4158…

Excited to share our AI+cryo-EM work! 🧬 🔬 Cryo-IEF: Foundation model trained on 65M particles 🤖 CryoWizard: automated structure pipeline 🎯 Making cryo-EM accessible to more labs Preprint: biorxiv.org/content/10.110… Code: github.com/westlake-repl/… #CryoEM #AI #StructuralBiology

We’re so exited about the community’s use of Boltz-1 already! We’ve just released a new update to of the Boltz-1 repo, which now automatically generates MSA’s for users in seconds using the amazing Colabfold MMseqs server. Test it out here: github.com/jwohlwend/boltz

View the new Collection on Machine Learning in Structural Biology here!

Transformers visually explained by Grant Sanderson (3blue1brown) youtu.be/KJtZARuO3JY

MIT and Genesis Therapeutics released Boltz-1, an open-source model matching AlphaFold3's accuracy in predicting biological structures Available for researchers worldwide under MIT license x.com/gabricorso/sta…

Tomorrow (Monday) Akhil Premkumar will present his "Neural Entropy" arxiv.org/abs/2409.03817 Join us on zoom at 9am PT / 12pm ET / 6pm CET: portal.valencelabs.com/logg

BioNemo framework from nvidia clara health division just released! arxiv.org/html/2411.1054… if you want to train your own esm2 / protein language model with nemo backend this would be very useful

New blogpost: The ABCs of Alphafold 3, Boltz and Chai-1 blog.booleanbiotech.com/alphafold3-bol…

Recent protein design webinar with Nobel laureate David Baker for a history of the field youtube.com/live/BuJGTn7Oh…

🚀 Announcing ColabSaprot v2! 🧬 Train your own protein language models instantly - no ML or coding expertise required. Everyone can do it in a few minutes! 📺 Video Tutorial: [youtube.com/watch?v=nmLtjl…] 💻 Try it: [colab.research.google.com/github/westlak…] 📄Paper: [biorxiv.org/content/10.110…]

A protein's position in the genome in relation to other genes is informative about function, so a genomic language model can be prompted to generate - toxin/antitoxin pairs - anti-CRISPR proteins + a database of 120B synthetic base pairs Aditi Merchant Samuel King Eric Nguyen Brian Hie