Here in Nature Synthesis I discuss with B. J. Rasor, Andreas M. Küffner and SYBORG developments and opportunities for biosynthesis of targeted chemicals from C1 compounds. I focused on in vitro approaches towards cell-free systems capable of self-sustaining ! nature.com/articles/s4416…

#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created. So, we compiled them and revisit the core concepts of growth coupling. sciencedirect.com/science/articl…

Review article now online: Building complex biochemicals from one-carbon compounds by Blake Rasor, Simone Giaveri, Andreas M. Küffner & Tobias Erb SYBORG nature.com/articles/s4416… ($)

Escherichia coli selection strains for growth-coupled metabolic engineering "growth-coupled selection brings synthetic metabolism to life" sciencedirect.com/science/articl…

Online now: Microbial/enzymatic light-induced NADPH regeneration electrochemical cells for continuous electrosynthesis of enantioselective products dlvr.it/TM1SLT

I am happy to share our pre-print on the genetically encoded control of in vitro DNA replication in the PURE system, including data comparing in vitro system setups and highly active phi29 DNAP mutants. Check it out! A big thank you to everybody SYBORG! t1p.de/e4yhl

🚨 New paper out in Trends in Biotechnology ! Join us on a journey toward light-powered, sustainable biomanufacturing 🌞🧪 Omer Yehezkeli MATAN MEIROVICH Technion Israel BFE.technion 🧵

Now published in Microbial Biotechnology! …icro-journals.onlinelibrary.wiley.com/doi/epdf/10.11…

Activation-Free Upgrading of Carboxylic Acids to Aldehydes and Alcohols biorxiv.org/content/10.110… #biorxiv_synbio

How can we enable biotechnology? Make protein faster!! Check out our new work in cell-free protein synthesis making ~1 g/l/h of protein. Led by the amazing Meagan Olsen Northwestern CSB biorxiv.org/content/10.110…

1/ 🚨 New preprint! We've developed a robust IDMS-based LC-MS/MS workflow for high-throughput intracellular metabolomics in diverse bacteria. biorxiv.org/content/10.110… #Metabolomics #MassSpec #SystemsBiology

Is your water safe to drink? Lead in drinking water is unsafe, but developing biosensors for detection is difficult. We used active-learning with directional tokens to develop a cell-free biosensor to detect lead in drinking water. w/ Northwestern CSB The Lucks Lab biorxiv.org/content/10.110…

Early-career scientists: here’s your chance to lead independent research!🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! mpg.de/career/max-pla…👉

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

Check out this job offer if you are a computational chemist and want to work at the cutting-edge of protein & enzyme design (or please share it with anyone who might be a good fit)!!

🚨 Paper Alert 🚨 We are excited that our work on controlling in vitro DNA replication in a reconstituted transcription-translation system (TTcDR) by using allosteric transcription factors has now been published in ACS Synthetic Biology! tinyurl.com/cvrtkkrn Check it out! :)

A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by Jediael Ng. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. biorxiv.org/content/10.110…

Our latest work on the nitrogenase-like methylthio-alkane reductase is now out Nature Catalysis doi.org/10.1038/s41929… We biochemically and structurally characterized the methylthio-alkane reductase, a metalloenzyme that can produce ethylene from organic sulfur compounds.

Growth-coupled microbial biosynthesis of the animal pigment xanthommatin — Led by Leah Bushin & featuring Maria Gracia Alvan Daniel Volke Òscar Puiggené González in a fantastic collaboration w/Bradley Moore UC San Diego DTU Biosustain Nature Biotechnology nature.com/articles/s4158…

Very excited to finally share my PhD paper, about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas. Huge thanks to the whole team! nature.com/articles/s4147…