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Excited to share my PhD work… and more CRISPR-Cas9 PAM variants than anybody asked for

Machine Learning Engineers Bespoke Cas9 Enzymes for Gene Editing Read more of what Ben Kleinstiver and Rachel Silverstein from HMS had to say in an interview with GEN's Fay Lin, PhD. MassGeneral News Harvard Medical School hubs.li/Q03jt42N0

We’re excited to share new work on the continuous in vivo evolution of gene libraries towards arbitrary functions. Led by superstar Olek Pisera, our experiments show that gene evolution is highly versatile...biorxiv.org/content/10.110…

Congratulations to David R. Liu on being named to the #TIME100Health list — honoring the 100 most influential people in health today. A well-deserved recognition!

"Does it work in human cells?" is a question I've gotten a lot this past year. Excited to share our latest work on bridge recombinases! It's been a lot of fun to lead this team effort. If you are excited to hear more, join for my thesis defense tomorrow at 3pm PT. Links below:

BREAKING: Last August, scientists secretly began creating a custom #CRISPR therapy to fix a mutation responsible for one baby’s debilitating disease. He was treated in February and doing better. My deep dive in Endpoints News has the details. endpts.com/philadelphia-d…

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j3xGs8

Today in Science Magazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with Sternberg Lab. 1/13 drive.google.com/file/d/1I-UbCR…

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…

A triumph of science, a miracle of medicine - built on decades of public investment into the US basic and translational biomedical research ecosystem. Magnificent effort led by Drs Rebecca Ahrens-nicklas (CHOP) and Kiran Musunuru (Penn) + IGI + Danaher. innovativegenomics.org/news/first-pat…