Brian Pico, MD (@bpicomd) 's Twitter Profile
Brian Pico, MD

@bpicomd

Hematologist/Oncologist @MCIStrong @mhshospital | GU Oncology | Tweets are my own.

ID: 1367319323782569993

calendar_today04-03-2021 03:41:58

98 Tweet

316 Followers

314 Following

Memorial Healthcare System (@mhshospital) 's Twitter Profile Photo

Did you know prostate cancer is the most common cancer seen in men? This Men's Health Awareness Month, Dr. Pico, hematologist & oncologist Memorial Cancer Institute, discusses the importance of annual check ups & prostate cancer screenings starting at the age of 50. 👉mhs.net/cancer

Tom Powles (@tompowles1) 's Twitter Profile Photo

Cabo+atezo in CRPC = ⬆️ rPFS (6.3 vs 4.2 mo HR 0.65(0.50-0.84). Immature OS 0.79(0.58-1.07). RR 13 vs 4%.We know Cabo mono has activity, and PD(L)1 has failed in CRPC. Therefore, without a Cabo mono arm it’s hard to know how much atezo is adding. Great job Neeraj Agarwal, MD, FASCO 👌⭐️#GU24

Cabo+atezo in CRPC = ⬆️ rPFS (6.3 vs 4.2 mo HR 0.65(0.50-0.84). Immature OS 0.79(0.58-1.07). RR 13 vs 4%.We know Cabo mono has activity, and PD(L)1 has failed in CRPC. Therefore, without a Cabo mono arm it’s hard to know how much atezo is adding. Great job  <a href="/neerajaiims/">Neeraj Agarwal, MD, FASCO</a> 👌⭐️#GU24
Tian Zhang, MD, MHS (@tiansterzhang) 's Twitter Profile Photo

#BRCAAway is still the most convincing reason to me that we should combine PARP with novel hormonal treatments — combo olaparib-abiraterone better than each monotherapy. Congrats #MahaHussain & team for this careful trial guiding #prostatecancer care. #GU24 ASCO OncoAlert

#BRCAAway is still the most convincing reason to me that we should combine PARP with novel hormonal treatments — combo olaparib-abiraterone better than each monotherapy. Congrats #MahaHussain &amp; team for this careful trial guiding #prostatecancer care. #GU24 <a href="/ASCO/">ASCO</a> <a href="/OncoAlert/">OncoAlert</a>
Brian Pico, MD (@bpicomd) 's Twitter Profile Photo

Excited for another GU ASCO in San Francisco celebrating 20 years of this excellent symposium! Great opening session in PC with talks by Dr M Hussain, Neeraj Agarwal, MD, FASCO, Dr K Hoffman and Dr C Hennequin #gu24 ASCO

Excited for another GU ASCO in San Francisco celebrating 20 years of this excellent symposium! Great opening session in PC with talks by Dr M Hussain, <a href="/neerajaiims/">Neeraj Agarwal, MD, FASCO</a>, Dr K Hoffman and Dr C Hennequin  #gu24 <a href="/ASCO/">ASCO</a>
Brian Pico, MD (@bpicomd) 's Twitter Profile Photo

Interim analysis of ANTICIPATE phase II trial presented by Matt Galsky showed pCR of 39% in APL-1202/Tislelizimab combination vs 21% Tislelizumab alone given as NACT in MIBC for cisplatin ineligible/declining pts with an acceptable safety profile. #GU24 ASCO

Interim analysis of ANTICIPATE phase II trial presented by <a href="/MattGalsky/">Matt Galsky</a> showed pCR of 39% in APL-1202/Tislelizimab combination vs 21% Tislelizumab alone given as NACT in MIBC for cisplatin ineligible/declining pts with an acceptable safety profile. #GU24 <a href="/ASCO/">ASCO</a>
Tom Powles (@tompowles1) 's Twitter Profile Photo

With a median FU up of ~5 yrs adjuvant pembro= 38% reduction in risk of death. The benefit is across subgroups (T stage etc). Subsequent therapy in 80% is relapses. The 1st +ve OS adjuvant PD1 study, making adjuvant pembro more attractive. #GU24 Toni Choueiri, MD

With a median FU up of ~5 yrs adjuvant pembro= 38% reduction in risk of death. The benefit is across subgroups (T stage etc). Subsequent therapy in 80% is relapses. The 1st +ve OS adjuvant PD1 study, making adjuvant pembro more attractive.  #GU24 <a href="/DrChoueiri/">Toni Choueiri, MD</a>
FLORIDA (@uf) 's Twitter Profile Photo

.Forbes names the University of Florida a “New Ivy” — recognizing UF’s top-performing graduates and the university leading higher education's evolution. news.ufl.edu/2024/04/forbes…

Yüksel Ürün (@dryukselurun) 's Twitter Profile Photo

Disappointing Results for Gilead’s Phase 3 TROPiCS-04 Study! ⭕️ Sacituzumab govitecan (Trodelvy) in metastatic urothelial cancer did not meet the primary endpoint of overall survival. ⭕️Increased deaths due to neutropenic complications were noted in the Trodelvy group. #Asco24

Disappointing Results for Gilead’s Phase 3 TROPiCS-04 Study!
⭕️ Sacituzumab govitecan (Trodelvy)
in metastatic urothelial cancer did not meet the primary endpoint of overall survival. 
⭕️Increased deaths due to neutropenic complications were noted in the Trodelvy group. 
#Asco24
Tom Powles (@tompowles1) 's Twitter Profile Photo

DFF332 (HIF2a inhibitor) was tested in heavily pretreated RCC. 5% response rates and some stable disease. HIF biomaker looked unhelpful, but more to do here. Belzutifan seems more active as a single again #ASCO24 Sumanta K. Pal, MD, FASCO

DFF332 (HIF2a inhibitor) was tested in heavily pretreated RCC. 5% response rates and some stable disease. HIF biomaker looked unhelpful, but more to do here. Belzutifan seems more active as a single again #ASCO24 <a href="/montypal/">Sumanta K. Pal, MD, FASCO</a>
Tom Powles (@tompowles1) 's Twitter Profile Photo

Preliminary SURE1 data shows neoadjuvant sacituzumab govitecan (n=21) required dose changes & GCSF to overcome toxicity. 33% didn’t have surgery making having responded efficacy hard to interpret. The trial goes on. pCR and ctDNA suggest activity but not transformative #ASCO24

Preliminary SURE1 data shows neoadjuvant sacituzumab govitecan (n=21) required dose changes &amp; GCSF to overcome toxicity. 33% didn’t have surgery making having responded efficacy hard to interpret. The trial goes on. pCR and ctDNA suggest activity but not transformative #ASCO24
Brian Pico, MD (@bpicomd) 's Twitter Profile Photo

Proud to be an investigator of this first-in-human phase I clinical trial for multiplexed T-cell receptor engineered T-cell therapy (TCR-T) for solid tumors. Come check out our poster at #ASCO24 #ASCO Memorial Cancer Institute !

Proud to be an investigator of this first-in-human phase I clinical trial for multiplexed T-cell receptor engineered T-cell therapy (TCR-T) for solid tumors. Come check out our poster at #ASCO24 #ASCO <a href="/MCIStrong/">Memorial Cancer Institute</a> !
Brian Pico, MD (@bpicomd) 's Twitter Profile Photo

First two days of #ASCO24 have been stellar thus far. Over 40,000 in-person and virtual attendees who share a common goal. Nothing like it. Grateful to be here to collaborate and learn. Memorial Cancer Institute

First two days of #ASCO24 have been stellar thus far. Over 40,000 in-person and virtual attendees who share a common goal. Nothing like it. Grateful to be here to collaborate and learn. <a href="/MCIStrong/">Memorial Cancer Institute</a>
Tom Powles (@tompowles1) 's Twitter Profile Photo

Perhaps the most important long-term bladder cancer data #ASCO24 Neoadjuvant Toripalimab & disitimab Vedotin in muscle invasive bladder cancer (n=47). pCR ⬆️ 63%. 14% G3/4 AEs. All surgeries occurred . The 1st MMAE/IO neoadjuvant combo data looks ✅✅. EV/IO MIBC trials awaited

Perhaps the most important long-term bladder cancer data #ASCO24 Neoadjuvant Toripalimab &amp; disitimab Vedotin in muscle invasive bladder cancer (n=47). pCR ⬆️ 63%. 14% G3/4 AEs. All surgeries occurred . The 1st MMAE/IO neoadjuvant combo data looks ✅✅. EV/IO MIBC trials awaited
Brian Pico, MD (@bpicomd) 's Twitter Profile Photo

Thank you Javier Romero and Univision 23 Miami for the invitation to discuss prostate cancer and the importance of early detection on their program, 'Contigo en la Comunidad'. Episode airs Saturday on Univisión. Memorial Healthcare System

Thank you <a href="/JavierRomerotv/">Javier Romero</a> and <a href="/Univision23/">Univision 23 Miami</a> for the invitation to discuss prostate cancer and the importance of early detection on their program, 'Contigo en la Comunidad'. Episode airs Saturday on Univisión. 

<a href="/mhshospital/">Memorial Healthcare System</a>
Dra. María Natalia Gandur Quiroga (@nataliagandur) 's Twitter Profile Photo

💫🌟📝 Key findings from the pembrolizumab study in kidney cancer: OncoAlert OncoReporte 🔬 First adjuvant therapy to improve overall survival in kidney cancer. 🧑‍🤝‍🧑 91% of patients on pembrolizumab alive at 4 years vs. 86% on placebo. ⏳ 40% reduction in the risk of death with

💫🌟📝 Key findings from the pembrolizumab study in kidney cancer:
<a href="/OncoAlert/">OncoAlert</a> <a href="/OncoReporte/">OncoReporte</a>
🔬 First adjuvant therapy to improve overall survival in kidney cancer.

🧑‍🤝‍🧑 91% of patients on pembrolizumab alive at 4 years vs. 86% on placebo.

⏳ 40% reduction in the risk of death with
Yüksel Ürün (@dryukselurun) 's Twitter Profile Photo

PORTOS predicts RT dose benefit in localized prostate cancer! Shuang Zhao, MD 🧬☢️In two phase III trials (NRG/RTOG 0126 & SAKK 09/10), the 24-gene PORTOS score identified patients who benefited from radiation dose escalation. @asco @oncoalert #GU25 #cancer #oncology

PORTOS predicts RT dose benefit in localized prostate cancer! Shuang Zhao, MD
🧬☢️In two phase III trials (NRG/RTOG 0126 &amp; SAKK 09/10), the 24-gene PORTOS score identified patients who benefited from radiation dose escalation.
@asco @oncoalert #GU25 #cancer #oncology
Tom Powles (@tompowles1) 's Twitter Profile Photo

TALAPR02 looks at Talazoparib/enza vs enza in 1st line CRPC . It has significant OS in ITT HR=0.796. It’s current used in HRR deficient. Subset analysis and wider data still supports the HRR biomarker OS (HRR deficient HR -0.54, HRR non-defficent/NA 0.87), but ITT OS is +ve #GU25

TALAPR02 looks at Talazoparib/enza vs enza in 1st line CRPC . It has significant OS in ITT HR=0.796. It’s current used in HRR deficient. Subset analysis and wider data still supports the HRR biomarker OS (HRR deficient HR -0.54, HRR non-defficent/NA 0.87), but ITT OS is +ve #GU25