Our study “Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids” is out! nature.com/articles/s4158… hubrecht.eu/scientists-dev… nature Hubrecht Institute Cambridge University Anna Alemany, vincentvB @Marloes_3015 Dr Naomi Moris, Peter Baillie-Benson Alfonso Martinez Arias A summary: (1/10)

A summary of my own views on the challenge to characterize the Waddington landscape of cell differentiation: europhysicsnews.org/articles/epn/a…

It was a lot of fun presenting at the #SCG2022 meeting! A lot of inspiration and novel concepts to integrate! Alexander van Oudenaarden vincentvB Amir Giladi Soufiane Mourragui Cansu Koyunlar Michael VanInsberghe Vivek Bhardwaj Marloes

Really enjoyed working on this and happy to be part of the team!

What happens when cells stop assemblying nucleosomes during DNA replication? We used CAF-1-degron human cells to answer this question, and look at the immediate effects within a single cell cycle. 🧵⬇️ biorxiv.org/content/10.110…

Hes genes are dynamically expressed in many tissues. But how do dynamics differ between tissues and are they always oscillatory? We have addressed this question in the context of the developing embryo, where somites and neural tube form side-by-side. biorxiv.org/content/10.110…

New scEdU-seq method developed by Alexander van Oudenaarden group measures DNAreplication speed in individual cells & may provide new insights into DNAreplication, embryonic development & cancer. hubrecht.eu/method-dna-rep… Jeroen van den Berg vincentvB Sergio Perez Acebron Anchel de Jaime-Soguero @marcelvanvugt Rinskje

scEdU-seq offers a tool to detect nascent, newly synthesized, DNA in single cells, enabling the study of replication fork speed in human cells. nature.com/articles/s4159… Jeroen van den Berg Alexander van Oudenaarden vincentvB @acebron Anchel de Jaime-Soguero @marcelvanvugt Rinskje

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to Raphael Pavani, Veenu Tripathi, and many terrific collaborators including Johannes Walter, Cejka Lab, Wei Wu. See science.org/doi/epdf/10.11…

One week left to apply, please get in touch if you want to learn more about the role and our teams. Sharing with your network is much appreciated!

Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: biorxiv.org/content/10.110…

How does genomic mosaicism arise during development? We identified that embryo patterning signals not only readour genetic blueprints to build organisms, but they also play a critical role in their maintenance. A quick dive into our new paper nature.com/articles/s4146… 1/10

Ready to establish your own research group at the Hubrecht Institute for molecular and developmental biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! hubrecht.eu/job/tenure-tra…

Researchers from the Mattiroli group discovered that DNA packaging in cells can directly impact the speed of DNA copying during cell division. The packaging sends signals through an unusual pathway, affecting the cell’s ability to divide and grow. More: hubrecht.eu/dna-packaging-…

Online Now: Acute multi-level response to defective de novo chromatin assembly in S-phase dlvr.it/TG85ld

Acute multi-level response to defective de novo chromatin assembly in S-phase (Dreyer et al., 2024) cell.com/molecular-cell…

Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work! sciencedirect.com/science/articl…

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s4158…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

#posting this again if any #postdoc candidates are interested in digging deep into #TCR #Crossreactivity #Tcell functional studies in #autoimmunity and #cancer -please contact me!