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ONLINE NOW: Beneath the radar: immune-evasive cell sources for stroke therapy dlvr.it/T1vkML

We now also published all datasets used in our previous study to support #openscience. Have a look if you are interested in preclinical #stroke #MRI and #histology sciencedirect.com/science/articl…

New preprint! 🚨Keck Medicine of USC Institute for Regenerative Medicine We started with the simple question: What happens when we transplant stem cells into a mouse model of #stroke, and what are the interactions between graft and host? Took us only 5 yrs to find out😀: biorxiv.org/content/10.110… 1/10 🧵

It was a pleasure to attend #FENS2024 in Vienna. I really enjoyed presenting my poster "Development of iPSC-derived neural progenitor cells with enhanced migration to stroke tissue and inducible ablation systems" together with Nora H. Rentsch and Rebecca Z. Weber

Happy to have contributed a small part to this well-composed Brain review 😆 Brain repair mechanisms after cell therapy for #Stroke Cell sources -/+ genetic engineering ▶️#NeuralStemCell ▶️#hiPSC-derived neural or vascular progenitors ▶️Cerebral #Organoid Direct

Happy to share our new paper published in PNASNews. growkudos.com/publications/1… via @growkudos I am incredibly grateful to all co-authors and contributors Bruno Weber Lab Daniel Razansky Susanne Wegener Institute of Pharmacology and Toxicology Unispital_USZ

Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out nature, we identify distinct TNF programs during tumor evolution. 🧵 nature.com/articles/s4158…

One more successful ERS today! 🤩 Thank you everyone who joined in Bern, all the nice presentations and networking! See you in February in Lausanne 🙌 #swissneuroscience

🚨Preprint: Stroke recovery is complex & involves major changes to all brain cell types. We dissect underlying molecular mechanisms in the repair phase 1 month post-stroke "A molecular brain atlas reveals cellular shifts during the repair phase of stroke" biorxiv.org/content/10.110…

Single-nuclei transcriptomics in Mouse Cortical #ischemicStroke (Photothromobosis) Reparative phase 4 wk post-stroke Infarct core vs Ischemic border zone vs Intact In Stroke core 👉Expansion of non-vascular #Pericyte 1⃣Take a look at their CD13+ arborized network😁

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells | Nature Neuroscience nature.com/articles/s4159…

After a long trip from Switzerland🇨🇭, CiRA welcomes Dr. Melanie Generali and young researchers Arian, Beatriz (Beatriz Achon Buil), Carmen, David (David Taborsky), Dennis, Nora (Nora H. Rentsch), and Vanessa from Institute for Regenerative Medicine for a 3-week SAKURA SCIENCE Exchange Program internship! ＃sakurascience #iPSC

After a "surprise" meet and greet with Dr. Shinya Yamanaka a day earlier, our SAKURA SCIENCE Exchange Program interns presented their research at the Kyoto University Intl Symposium: CiRA Institute for Regenerative Medicine Joint Symposium 2024 "Driving Next-generation Cell and Gene Therapy" this week! #sakurascience #iPSC

The first SAKURA SCIENCE Exchange Program internship with participants from Switzerland🇨🇭ended today with a series of final presentations by the Institute for Regenerative Medicine early career researchers about their research at CiRA during the past 3 weeks and a certificate presentation by CiRA Director Jun Takahashi!

Stem cell therapies hold great potential for stroke recovery; but when is the optimal time for transplantation? 🧠💉⏲️ Our latest preprint shows that delaying NPC therapy by one week post-stroke increases long-term graft survival 20-fold. biorxiv.org/content/10.110…

New review from our lab in Brain We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more! academic.oup.com/brain/advance-…

🚨 New paper: Much of stroke research focuses on acute injury - but what changes in the brain one month after stroke? We mapped cellular and molecular shifts in the brain during the repair phase | J Neuroinflammation BMC 🧬🧠 👇

🚨 Our new study out in Advanced Science Advanced Portfolio News! "Time is Brain" - is also true for cell therapies! Our work shows that delaying neural stem cell (NSC) therapy after stroke avoids the hostile early environment, increasing cell therapy success! 🧠 Transplanting NPCs at

Our review is now out in Brain! We discuss how the blood-brain barrier can both help and hinder brain function and drug delivery. We focus on aging, stroke, and Alzheimer’s disease and how these conditions impact the BBB. Check it out (open access): academic.oup.com/brain/article/…