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This preprint has grown into a fully published paper! 🎉 Hope you enjoy the read 🤗 nature.com/articles/s4159…

Published today Nature Communications , We show many fusion oncoproteins form cellular condensates. Through sequence feature analysis and machine learning, we found nuclear puncta are hubs for gene regulation, while cytoplasmic puncta promote cell signaling. rdcu.be/dneM5

Excited to have the final part of my graduate work from the Kadoch Lab Dana-Farber Dana-Farber News out today in Cell, where we dissect the (exciting!) role of ARID1A and ARID1B, two of the most mutated mSWI/SNF complex subunits! cell.com/cell/fulltext/…

Happy to share our study in Nature Chemical Biology showing that small molecules partition selectively into biomolecular condensates that compartmentalize the cell! With Richard Young Regina Barzilay Henry Kilgore Peter G Mikhael Catherine Van Dongen Link: nature.com/articles/s4158… PDF: rdcu.be/dngWY

An 11th grade student from Westford MA asks: what are condensates? Thank you postdoc Alessandra Dall'Agnese for answering their question! Our latest #AskaScientist video is published on BioNook, Whitehead Institute's online biology resource: wi.mit.edu/bionook/ask-a-…

Excited to share my third piece of postdoc work from the Eric N. Olson lab! This is a collaborative work with Ben Sabari Mikayla Eppert. We show that coactivator condensates regulate cell lineage specification. science.org/doi/10.1126/sc…

Excited to share a new collaborative paper from my lab and the @transactivators lab where we find that condensate formation of the cell type specific coactivator Myocardin drives gene activation during cardiovascular differentiation. science.org/doi/10.1126/sc…

A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in nature for nuclear speckles and mRNA splicing. Check out this thread! nature.com/articles/s4158…

Amazing review with very insightful analogies! Highly recommended! By Jared Bard and D. Allan Drummond.

Checkout the latest work from the lab online today in Molecular Cell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by Nancy De La Cruz Prashant Pradhan and Reshma T Veettil .

#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. bit.ly/3MQjHIr Lasker Foundation

Excited to share that our paper cell.com/molecular-cell… got the cover of the new issue of Molecular Cell. Extra cool that this is a photograph taken by the first author Nancy De La Cruz, a super-star research assistant and post-bacc who just started grad school UTSW Graduate School of Biomedical Sciences

Pre-print alert! With experimental collaborators at the Young lab (MIT), we investigate how (i)active rRNA transcription maintains the size, spacing, and number of nucleolar fibrillar centers, (ii) the consequence of this arrangement on rRNA processing. biorxiv.org/content/10.110…

I am excited to share our review, published online today Nature Reviews Molecular Cell Biology. Pilong Li, Gaofeng Pei, Heankel Lyons, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…

Many chronic diseases have a common denominator that could be driving their dysfunction: reduced protein mobility, which in turn reduces protein function. A new paper from Richard Young's lab describes this pervasive mobility defect: wi.mit.edu/news/cellular-…

What drives two liquid droplets to merge? The usual answer is surface tension. This picture is slightly different for biological condensates. To know more, please check out our recent Biophysical Journal paper: doi.org/10.1016/j.bpj.… Harvard Chemistry Shakhnovich Lab

Riaz Gillani, MD, and Ryan Collins in Eli Van Allen Dana-Farber report in Science Magazine that rare germline genetic abnormalities increase the risk of pediatric solid cancers, findings that could help improve treatments and screening. ➡️ bit.ly/3BQ04hK

I am happy to share that I have joined North Dakota State University as an Assistant Professor in the Department of Chemistry and Biochemistry. ndsu.edu/chemistry/peop…

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. cell.com/cell/fulltext/….

ITOA is catching on