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Are you interested in joining our multidisciplinary team at Cardiovascular Research Institute Maastricht (CARIM) as a PhD candidate in vascular biomechanics? Apply below! academictransfer.com/en/335444/phd-… CARIM Maastricht University ARTERY Society VascAgeNet

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Guto Montezano Q2 1/3 non-invasive pulse wave velocity is the most used way to assess arterial stiffness. It is a reliable biomarker of #vascularageing, because it represents the integrated effect of normal ageing and risk factors on the aorta #HYPHIP @Hyper_AHA Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Guto Montezano Q2 2/3 pulse wave velocity #PWV predicts cardiovascular events in the general population, especially in the young, and it is useful in reclassifying patients at a higher risk category – see sciencedirect.com/science/articl…

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Guto Montezano 3/3 #PWV is also recommended to assess #hypertension -mediated organ damage by European Society of Hypertension journals.lww.com/jhypertension/… For more info VascAgeNet released a webinar series on #vascular ageing youtube.com/playlist?list=…

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck 4 - no, but we tried to follow as much as possible their criteria (i.e. for #BP monitors)

Sarah Melville Tanja Dudenbostel, MD, FASH, FAHA ISO Currently, ours is not. Our statistical methodology is very similar though to the ISO guidelines for blood pressure device validation (81060-2:2018) #HYPHIP @Hyper_AHA Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Rosa Maria Bruno Dimitrios Terentes-Printzios Ana J Elisabetta Bianchini

A4. #HYPHIP @Hyper_AHA Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Rosa Maria Bruno

Sarah Melville Bart Spronck Tanja Dudenbostel, MD, FASH, FAHA ISO Dimitrios Terentes-Printzios Ana J Elisabetta Bianchini Prof Alta Schutte #BP validation experts such as Prof Alta Schutte were invited on purpose, to ensure quality of our #PWV validation recommendations 😉

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Hypertension Guto Montezano Carmen De Miguel, PhD, MS, FAHA Sarah Melville A8 1/2 we decided to be independent from industry, to provide an unbiased look to #PWV device validation #HYPHIP Hypertension Tanja Dudenbostel, MD, FASH, FAHA Guto Montezano Carmen De Miguel, PhD, MS, FAHA Sarah Melville

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Hypertension Guto Montezano Carmen De Miguel, PhD, MS, FAHA Sarah Melville A8 2/2 we included some people with experience in industry field , but only those without conflict of interest #HYPHIP Hypertension Tanja Dudenbostel, MD, FASH, FAHA Guto Montezano Carmen De Miguel, PhD, MS, FAHA Sarah Melville

Guto Montezano Bart Spronck Tanja Dudenbostel, MD, FASH, FAHA A9 1/2 Strange but true, there are not so many published sex-disaggregated data on prediction of CV prognosis by #PWV. Current data suggest that #vascularageing is accelerated in women compared to men starting from 30 years old (well before menopause!)

Guto Montezano Bart Spronck Tanja Dudenbostel, MD, FASH, FAHA A9 2/2 #vascularageing in women is influenced by both sex- and gender-related factors. There’s lot of work to do on this topic! For a review on this topic, see nature.com/articles/s4137… @Hyper_AHA Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck VascAgeNet

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck A11 1/2 Severe obesity can be a challenge indeed, especially taking the femoral arterial waveform by tonometry. However, cuff devices are now available for non-invasive carotid-femoral and brachial-ankle #PWV, making things much easier. Cardiac echo may be much more challenging!!

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck A11 2/2 This is why we recommended that specific validation studies are required in severely obese individuals – as well as in pregnant women, children and adolescents – in those cases hemodynamic conditions may be different #HYPHIP @Hyper_AHA Tanja Dudenbostel, MD, FASH, FAHA VascAgeNet

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Guto Montezano A12 unfortunately not, at least to my knowledge! Furthermore carotid-femoral and brachial-ankle PWV are regional measures, while calcifications are focal 🤷

Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck Hypertension A14 not yet, but this is a great idea Tanja Dudenbostel, MD, FASH, FAHA !!!! #HYPHIP @Hyper_AHA Tanja Dudenbostel, MD, FASH, FAHA Bart Spronck VascAgeNet Guto Montezano

Dream team!

An excellent opportunity for all CARIM PhDs to contribute to all aspects of a CARIM PhD and broaden your network!

We are hiring a PhD in vascular biomechanics and digital twinning, as part of the VITAL consortium (vital-horizoneurope.eu)! Apply here: tinyurl.com/vitalphd Deadline: 31 Jul 2024! VITAL CARIM Maastricht University ARTERY Society #academicjobs #PhDpositions