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LLPS meets CRISPR/Cas 9 gene editing. In our latest paper in ACS Nano, we show how peptide-based coacervates can easily deliver inside cells CRISPR/Cas9 modalities, including the challenging RNP complex. #llps #biocondensates #CRISPR #coacervates pubs.acs.org/doi/abs/10.102…

One ring to rule them all. A single peptide delivers DNA, mRNA, or CRISPR Cas9 ribonucleoprotein better than lipofectamine 2k, 3k, CRISPRMax. More efficient gene editing. pubs.acs.org/doi/abs/10.102… Nice collab with BBML_NTU!

I am so proud to be on the first page of ⁦ETH Zurich, with my great colleague Ali Miserez ⁦BBML_NTU⁩ for this amazing invention: Generating #clean #electricity with chicken feathers | ETH Zurich. BIG CONGRATS ⁦Wei Long Soon⁩ ⁦Mohammad Peydayesh⁩ ethz.ch/en/news-and-ev…

ntu.edu.sg/news/detail/po…. 40 Millions tons of chicken feathers are produced annually and burnt, producing toxic sulfur dioxide. Wei Long Soon from BBML_NTU has converted chicken feathers into membranes for fuel cells. Great collaboration with the lab of Raffaele Mezzenga!

Fluid #protein #condensates for #bioinspired applications. Check out our latest review on #LLPS and #LLCPS on Nature Reviews Bioengineering Nature Reviews Bioengineering with BBML_NTU and Matthew J. Harrington - nature.com/articles/s4422…

Was an absolute pleasure to work on this review on fluid protein condensates in biological and bio-inspired materials fabrication with Ali @bbmlntu and Raffaele Raffaele Mezzenga !

Fluid protein condensates, such as elastin and spider silk, can inspire the design of high-performance fibres, adhesives and composites for bioengineered materials! New Review by Raffaele Mezzenga Matthew J. Harrington BBML_NTU go.nature.com/3twRErl

We should never forget that every technological or biomedical breakthrough initially started with basic, blue-sky research. An example from our lab reviews in this recent Account of Chemical Research. pubs.acs.org/doi/abs/10.102…

The viscoelastic properties of peptide coacervates correlate to their structures, reported by BBML_NTU nature.com/articles/s4200…

Latest phase-transition paper from our team: Using transfer NOESY NMR and neutron scattering to study the hierarchical structure of coacervates and the dynamic interactions of their building blocks. Phase Transition Papers biorxiv.org/content/10.110…

Manuscript accepted in @AdvSciNews. (Very) high publication fees paid and yet after a few weeks, manuscript still not available on-line. New experiment: will posting a complaint in social media get the journal to act ?

onlinelibrary.wiley.com/doi/10.1002/ad…. Peptide condensates are very versatile vehicles to deliver large macromolecules into cells (genes, mRNA, proteins). We have finally unveiled how they enter cells. Phase Transition Papers

Phase separating peptides coacervates enter cells by a dual macropinocytosis/phagocytosis pathway. This SEM picture from our lab on the cover of Advanced Science is arguably a textbook example of macropinocytosis. onlinelibrary.wiley.com/toc/21983844/2…

Ticks join the ranks of organisms that exploit phase separation to produce strong biological adhesives. I enjoyed writing this News and Views perspective of this recent research article published in Nature Chemistry, full tex here: rdcu.be/d7cZG Phase Transition Papers