🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Massive experimental quantification of amyloid nucleation allows interpretable deep learning of protein aggregation 1. This study presents a revolutionary dataset of amyloid nucleation for over 100,000 protein sequences, addressing the limitations of previous aggregation

Join us online to explore how synthetic-based technologies are being translated into solutions for #HumanHealth and sustainability. #SynBio  Network online with academic and #biotech leaders at #SynBio24. 🖥️ ⏰Register for a virtual place by 15 October: bit.ly/3uuK7tM

this year's Wellcome Sanger Institute Janet Thornton Fellowship scheme is now open -- this is for postdocs who have left science for 12 months for any reason and want to return -- read more about its history in the thread below, and find out about 8 projects here sanger.ac.uk/about/equality…

Our paper on deep mutagenesis of JUN’s interaction with the 54 human bZIP is now out in Nature Communications rdcu.be/dWXmn Great work from @AlexBendel_, with Andre Faure @ajfaure.bsky.social and Ben Lehner Thread in quoted post 👇

The genetic architecture of protein interaction affinity and specificity nature.com/articles/s4146… by Guillaume Diss @AlexBendel_ + Andre Faure @ajfaure.bsky.social

MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data • This study introduces MoCHI, a tool designed to analyze deep mutational scanning (DMS) data by fitting interpretable

We think this demonstrates massive potential for pharmacological chaperones for treating a large number of individuals with a broad range of genetic diseases. Check out the pre-print here: biorxiv.org/content/10.110…

Can a single small molecule rescue the stability of nearly all mutations in a protein? Our new preprint by Taylor Mighell + thread biorxiv.org/content/10.110…

Site-saturation mutagenesis of 500 human protein domains: nature.com/articles/s4158…

The first ‘human domainome’ reveals the cause of a multitude of diseases. An ingenious large-scale experiment in Barcelona (by Toni Beltran & Ben Lehner) has led to the creation of a catalog detailing the effects of half a million DNA mutations: english.elpais.com/science-tech/2…

Protein instability is the main driver of inherited genetic conditions, according to the largest map of protein variants to date − Human Domainome 1.0🔎 This dataset can help predict how proteins behave, paving the way for new treatments💊 sanger.ac.uk/news_item/huma…

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by Ben Lehner and Toni Beltran Toni Beltran is out in nature. ✍️ Illustration by Queralt Tolosa, PhD

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 @LeopoldParts, Pierre Murat

I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases Science Magazine! Raphael Ferreira @LeopoldParts Tom Ellis, george church @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵

If you’d like to work in this exciting science area, @LeopoldParts lab at the Wellcome Sanger Institute is hiring postdocs! This is all part of the new Generative and Synthetic Genomics programme with nearby @benlehner and Jussi Taipale sanger.wd103.myworkdayjobs.com/en-US/Wellcome…

3 great computational positions open at ALLOX to work with the great Andre Faure @ajfaure.bsky.social Júlia Domingo Pablo Baeza Centurion Mseu

Could #AI be a game-changer for #BiologicalResearch? Join us for #AIxBio25, our new conference on the transformative potential of #AI and #MachineLearning, in shaping the future of medical science. 📅Save the date: 23-25 June 2025 📎 Find out more: bit.ly/4gh164E

I’m excited to co-host the new #AIxBio conference alongside Žiga Avsec, Noelia Ferruz, Patrick Hsu, Ben Lehner, mary jane, Debora Marks, Tingying Peng, @CarolineUhlerat at Wellcome Genome Campus/ Wellcome Sanger Institute! We’ll focus on modellingz and designing DNA, RNA, proteins, and cells, as well as

New publication. We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With Benedetta Bolognesi Centre for Genomic Regulation (CRG) Wellcome Sanger Institute IBEC science.org/doi/10.1126/sc…

Come and join us! We’re hiring a new Group Leader in Generative Biology at the Wellcome Sanger Institute Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. pls RT! nature.com/naturecareers/… acrobat.adobe.com/id/urn:aaid:sc…