Thanks to Ontario Government for support of our research on how to more effectively treat small cell lung cancer - this funding will propel our work on behalf of Ontarians and beyond. 🙏

Proud to be a part of this cohort and to be promoted at Radiation Oncology - congrats to my fellow colleagues!🎉🎉🎉 Catherine Coolens Jennifer Croke (she/her) Alexandra Rink Danielle Rodin #TeodorStanescu Danny Vesprini and thanks to mentors, colleagues, and my family for all their support+encouragement! 🙏

This week marks 1 year since we initiated NET tissue biobanking. Today, we received tissue samples from the 40th patient. We want to take this opportunity to express our deep gratitude to all the patients who have generously donated samples. Julie Hallet Neuroendocrine Cancer Research Foundation Terry Fox Research Institute

No SUNSET on this ultracentral trial of 60 Gy in 8 fractions <7% grade 3-5 AEs, ~90% local control Online at: redjournal.org/article/S0360-… Meredith Giuliani Benjamin Lok, MD Alex Louie MD, PhD Houda Bahig, MD PhD Andrea Bezjak Scott Bratman David Palma, MD, PhD

Congratulations to Meredith Giuliani on being inducted as a Fellow of ASCO - a big honor 🏆🏆🏆 All of us at Radiation Medicine Program Radiation Oncology Princess Margaret Cancer Centre Princess Margaret Cancer Centre Research University Health Network are very proud of you 🎉🎊🎉 David Kirsch, MD, PhD Laura Dawson @akeithstewart #ASCO24

Congratulations to Lillian Siu for being this year's ASCO David Karnofsky Memorial Award #ASCO24 recipient 🏆+ delivering an inspiring award lecture!🎇🎆 Princess Margaret Cancer Centre Princess Margaret Cancer Centre Research University Health Network @akeithstewart

Welcome to Advances in Radiation Oncology's X account! Follow us here to read about the latest advances in our field and to learn about innovative scholarship emerging from our specialty! #ASTRO24

We’re here on the first day of #ASTRO24, bringing you educational content from our journal! Follow & spread the word!

Connect with Editor-in-Chief, Rachel Jimenez, MD at the ASTRO Meter Board, happening now at the ASTRO Resource Center! Learn more about the future of the journal and how to get involved! #ASTRO24 Benjamin Lok, MD Krishan Jethwa @stevebraunstein Henning Willers, MD, FASTRO

Keep your 👀's on Advances, an ASTRO Journal Editorial Board and give us a follow because there is more content headed your way! #ASTRO24 @khintenlang @JillRemickMD Benjamin Lok, MD Miranda Lam @stevebraunstein @mknoll_md Adam Currey Jing Zeng Krishan Jethwa Rachel Jimenez, MD

#ASTRO24 Terrific early morning #lungcancer session🫁‼️ Benjamin Lok, MD reporting on tolerability of PARPi with IMRT as consolidation in patients with ES-SCLC🙏 Important to restrict esophagitis‼️ Excellent basis for future development of PARPi in this space👍 #LCSM

Pleasure to run into Benjamin Lok, MD at #ASTRO24 👍 Advances, an ASTRO Journal & IJROBP - The Red Journal #RadBio Section editors committed to promoting robust & translational radiation biology research 😊😊 📢And we welcome your submissions🙏🙏 Sue Yom Rachel Jimenez, MD

Is PARPi safe with consolidative RT in ES-SCLC? 🔊Seems so Ph1 presented by Benjamin Lok, MD at #ASTRO24 of Talazoparib concurrent with RT. 👉MTD of talazoparib with RT is 1 mg 👉5% Grade 3 and 55% Grade 1-2 oesophagitis 👉No new safety signals ⏭️Future combos with IO and BiTEs

🔬 New strategy to boost immunotherapy for small cell lung cancer (SCLC): Combining PARP inhibitors + radiotherapy activates immune pathways & boosts T cell-attracting chemokines, discovered by Benjamin Lok, MD’s team at University Health Network Princess Margaret Cancer Centre. Read in Nature Communications: nature.com/articles/s4146…

🧬 The team also found that PRMT inhibitor could improve SCLC treatment outcomes from an epigenetic point of view: A PRMT inhibitor (MS023) disrupts splicing, increases DNA damage & shows strong synergy with chemo & radiation. Published in Neoplasia: doi.org/10.1016/j.neo.…

A team led by Dr. Benjamin Lok, MD University Health Network has found a new target to enhance radiation therapy in small cell lung cancer. By removing the function of gene HDAC3, cancer cells became more sensitive to radiation and tumour growth was inhibited: uhnresearch.ca/news/increasin…; aacrjournals.org/mct/article/do…

Researchers at Princess Margaret Cancer Centre Research have identified a potential new target to enhance radiation therapy for #SmallCellLungCancer. Blocking HDAC3 protein function makes cancer cells more sensitive to radiation. 🔗 Read more: uhnresearch.ca/news/increasin…