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Nature research paper: A polyene macrolide targeting phospholipids in the fungal cell membrane ttps://www.nature.com/articles/s41586-025-08678-9

A paper in nature describes the discovery of a new preclinical compound with strong antifungal activity against multidrug-resistant pathogens. go.nature.com/4j20vFx

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome go.nature.com/3FJLuu0

Someone made a helpful guide to accessing scientific papers:

Uncovering the Molecular Landscape of Tetracycline Family Natural Products through Bacterial Genome Mining | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

A heme-dependent enzyme forms the hydrazine in the antibiotic negamycin nature.com/articles/s4158…

Design and Biosynthesis of Ornithine 8-Containing Semaglutide Variants with a Click Chemistry-Modifiable Position 26 | ACS Synthetic Biology pubs.acs.org/doi/full/10.10…

➡️#chimie ⚗️ #ResultatScientifique 📕🔎l Les molécules essentielles au fonctionnement cellulaire et à l’apparition de la vie sur Terre peuvent se former dans l’espace au sein des glaces interstellaires 🤝Institut Chimie Nice CNRS Côte d’Azur ➡️ cnrs.fr/fr/presse/les-…

A symbiotic filamentous gut fungus (Fusarium foetens) ameliorates MASH (metabolic dysfunction–associated steatohepatitis) via a secondary metabolite–CerS6–ceramide axis | Science science.org/doi/full/10.11…

Convergent acquisition of disulfide-forming enzymes in malodorous flowers | Science science.org/doi/10.1126/sc… … wondering whether a similar evolutionary mechanism also evolved in malodorous mushrooms 🍄‍🟫

Check out our illisimonin A total synthesis J. Am. Chem. Soc. and find out how we make an olefin dance around the ring! Total Synthesis of (−)-Illisimonin A Enabled by Pattern Recognition and Olefin Transposition | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

We are pleased to share our latest work on site- and epimer-selective hydrogenations of thiostrepton, published in J. Am. Chem. Soc.! Congratulations Paul Paul Peterson for navigating catalyst control in a high-complexity molecule, unveiling some unexpected SAR. pubs.acs.org/doi/10.1021/ja…

Catalyst-Controlled Site-Selective and Epimer-Selective Hydrogenations of Thiostrepton | Journal of the American Chemical Society Yale University Yale Chemistry Total Synthesis and Methodology Highlights pubs.acs.org/doi/10.1021/ja…

Pancreatic cancer cells express cryptic peptides shared across patients that may be therapeutic targets, according to new research in Science. 📄: scim.ag/4mmkSQz #SciencePerspective: scim.ag/4kgEKCH

Discovery of acylsulfenic acid-featuring natural product sulfenicin & characterization of its #biosynthesis by Xue, Zou, Qiu, Lv, Madden, Xu, Lian, Pulliam, Ethan Older, Hou, Campbell, Tristan de Rond, Awakawa, Yuan, Bradley Moore in Scripps Institution of Oceanography, Li nature.com/articles/s4155…

DNA Synthesis and Assembly Technologies: From Oligonucleotides to Complete Genomes

The story of a structural sage nature.com/articles/s4157… 🧪

Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Structural Determinants of Buprenorphine Partial Agonism at the μ-Opioid Receptor #MolecularDynamics #Docking pubs.acs.org/doi/10.1021/ac… Institut de Neurociències UAB #JCIM Vol65 Issue10 #compchem