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Excited to share our latest research in Nature Communications! Discover how SUMOylation of Warts kinase promotes neural stem cell reactivation. Gao Yang JIAEN LIN Mahekta Gujar Luke Kun-Yang Lin Read the full paper here: nature.com/articles/s4146…

#ExM has transformed how we perceive the microbial diversity all around us. Some gorgeous critters from the EMBL Heidelberg pond - DNA red, centrin yellow, tubulin gray, images courtesy @F_Mikus. Bonus points if you can identify at least 4! Want more? biorxiv.org/content/10.110…

Thrilled to share our latest work from my postdoc with Adam Martin in Developmental Cell ! We uncovered a mechanism linking DV axial patterning with AP axis extension through patterned cell-cell adhesion. Intrigued? Dive into the details here!

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

Happy fluorescence Friday from this Xenopus tadpole head highlighting migrating microglia (green) and neurons (magenta) 🐸🔬🧠 By: Micaela Lasser, Helen Willsey Helen Willsey lab ZEISS Microscopy Axiozoom + apotome

Even our embryos are starting to feel a little festive in the Srinivas lab! We are happy to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo biorxiv.org/content/10.110…

It took a lot of effort to figure out, but here it is: the Drosophila haltere displays wing-like dorsoventral adhesion (surprise!) and that is essential for shaping its 3D architecture in a very interesting way biorxiv.org/content/10.110…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

First paper of our lab today nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! EMBL doi.org/10.1038/s41586…

This week we were happy to announce the winner of the Royal Society Publishing 2024. 'The hunt from above' by Dr Angela Albi is a stunning bird's-eye view of four sharks hunting a group of schooling fish in the crystal-clear waters of the Maldives. Find out more:

A simple MiMIC-based approach for tagging endogenous genes to visualise live transcription in Drosophila Read this Techniques and Resources Article by Lauren Forbes Beadle, Catherine Sutcliffe and Hilary Ashe The Ashe lab The University of Manchester: doi.org/10.1242/dev.20…

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! biorxiv.org/content/10.110…

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. nature.com/articles/s4159…

Cellpose3: one-click image restoration for improved cellular segmentation Carsen Stringer & Marius Pachitariu nature.com/articles/s4159…

I am thrilled that our work on MemGraft probes for “permanent” fluorescent labelling of plasma membranes is out in JACS Au! We established a concept of lipid-directed covalent labeling of plasma membranes. Open access: pubs.acs.org/doi/10.1021/ja… MemGraft probes allow cell fixation,

Our new preprint is out＠bioRxiv: biorxiv.org/content/10.110… Masa A. Shimazoe et al. reveal that linker histone H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with Rosana Collepardo, Charlie Phillips, Jan Huertas and others—huge thanks! 🙌 1/2

Stoked to present our latest, brilliantly led by Chris et al & Alejandro Torres-Sanchez. How tissues are patterned during development – we found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n biorxiv.org/content/10.110…

🧬A new imaging technique developed by the Liu Lab uses a novel DNA barcode system to track hundreds of RNA & protein molecules in single cells within thick biological samples, providing a full picture of how these structures are organized inside tissues. janelia.org/news/new-metho…

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: cell.com/cell/fulltext/…

Our new paper is out Science Advances👇 science.org/doi/10.1126/sc… 🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells. 🔍Katsuhiko Minami et al.have developed a chromatin behavior atlas within the nucleus. 1/2