
Ben Reisman MD PhD
@benjaminreisman
Onc Fellow @Hopkins_HemOnc via @OslerResidency + @VanderbiltMSTP โข chemical biologist โ๏ธ
ID: 471303604
22-01-2012 18:28:10
1,1K Tweet
1,1K Followers
2,2K Following

We know the importance of subtle gene dosage variation, and yet the main tool of molbio is gene KO/KD. In our new preprint, Jรบlia Domingo introduced subtle modulations of transcription factor dosage by CRISPRi/a, and quantified responses by scRNA-seq. 1/ biorxiv.org/content/10.110โฆ

A new study from Alex Bick & Ferrell Lab labs led by incredible Brett Heimlich, Pawan Bhat & Alyssa Parker! Comprehensive multi-omic profiling of 66968 single cells unveils that TET2 & DNMT3A mutations in Clonal Hematopoiesis drive distinct inflammatory pathways,




Beyond excited to share my first paper from my PhD Daniel Fazakerley Lab Inst Metabolic Science-Metabolic Research Labs now out in The EMBO Journal! Special thanks to Sam from TVPLab and Dougall Norris for co-leading this project with me. We found that many cell culture models, despite living in 18% oxygen, are hypoxic! ๐งตbelow:

#Thayer team supporting #SaySarcoidosis #Awareness Campaign #FindACure! The Osler Medical Residency and they #challenge the #Barker firm to #SaySarcoidosis #sarcoidosis Johns Hopkins Department of Medicine Hopkins Pulmonary and Critical Care Medicine Johns Hopkins Rheumatology @mwsharp5 Stuart Ray Sanjay Desai



Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110โฆ #2: biorxiv.org/content/10.110โฆ


A single SNP in ~10% of US African Ancestry individuals causes a systematic decrease in HbA1c and a dramatic under treatment of diabetes. In Nature Medicine led by Joseph Breeyear Jacklyn Hellwege Ayush Giri Todd Edwards Vanderbilt University Medical Center nature.com/articles/s4159โฆ



๐ @WashUHeme is recruiting!!!๐คฉ We are seeking physician-scientist, clinical & research faculty candidates to join our expanding #HemeDreamTeam! More details here: facultyopportunities.wustl.edu/Posting/Detailโฆ facultyopportunities.wustl.edu/Posting/Detailโฆ facultyopportunities.wustl.edu/Posting/Detailโฆ hematology.wustl.edu @WUDeptMedicine



๐ข New KFW Lab paper out now in Science Advances! ๐ข We show that AML cells resist chemotherapy by reversing the ATP synthase reactionโsupporting oxidative metabolism and maintaining mitochondrial membrane potential. ๐ฌ๐งฌ ๐ science.org/doi/10.1126/scโฆ


1/ Our new review is out today in Nature Reviews Cancerโon why therapeutic cancer vaccines are finally gaining traction after decades of setbacks. ๐ rdcu.be/emkkd w/ Dr. Neeha Zaidi Dr. Elizabeth Jaffee Key takeaways below
