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Great work by first authors: Doris Kaltenecker, izabela_horvath, Rami, Ilgın Kolabas, Ying Chen, at Helmholtz Munich | @HelmholtzMunich Universität München

Diseases like obesity affect multiple organ systems, highlighting the interconnected nature of our body's physiology. To truly understand these systemic effects, we need holistic tools for studying cellular changes on a whole-body scale.

The different AI-modules have been trained with a unique reference data set generated in virtual reality to faithfully perform nerve, immune cell and organ/tissue segmentation.

We found significant changes in the facial trigeminal nerve of obese mice, particularly in the infraorbital nerve, which is crucial for sensory perception. This potentially explains the reduced whisker sensitivity observed in these mice.

Using MouseMapper, we also quantified immune cell clusters in obese mice, confirming elevated inflammation across tissues and shifts in CD68-EGFP+-cell cluster sizes, providing detailed spatial insights into how obesity drives systemic inflammation.

Why This Matters: Understanding how obesity affects the body at a systemic level can lead to better treatments. MouseMapper enables researchers to identify new therapeutic targets by revealing how different tissues and organs are impacted.

Data Accessibility: We’re making the data and algorithms behind MouseMapper freely available. Feel free to explore the obesity-induced changes in different tissues/organs via our online atlas.

Applications Beyond Obesity: While this study focuses on obesity, MouseMapper's versatility makes it a powerful tool for studying other complex conditions, such as neurodegenerative diseases, cancer, and cardiovascular diseases. The possibilities are vast.

Future Directions: We’re excited about the potential of MouseMapper to evolve and be customized for different research needs. What other diseases could we map next? The journey is just beginning!

#HelmholtzDiabetes2024 Prof. Teresa Zimmers, Oregon Health & Science University, is renowned for her innovative work in #cancer #cachexia. Check out her #interview on the 11th #HelmholtzDiabetesConference! 👇 💬She says: "This conference is very stimulating to bring new ideas

30 posters were presented during the Diabetes Conference, showcasing cutting-edge research on wasting metabolism! 🎉 Congratulations to Leonardo Matta for winning the #PosterPrize, sponsored by EMBO. 🏆 Thank you to all the participants for their inspiring contributions! 🙏

And the winners of the 2024 HeIDi Award are... 🥁: Huge congratulations to Roberta Sartori (Università di Padova) and Sarah Stern 🎗️ (Max Planck Florida Institute for Neuroscience)! This award celebrates exceptional young scientists in #diabetes research. 🌟 #HelmholtzDiabetes2024

Thank you so much to all the speakers, participants, and sponsors for making our 11th Helmholtz Diabetes Conference such a success. 🙏 We’re excited to announce the dates for the next one: 22–24 September 2025. 📅 See you next year! 🙌 #MarkYourCalendar #HelmholtzDiabetes2025

I had massive fun and learnt a lot over the last few days, but this was the cherry on top! 😊🎉 Thank you very much to the organizers for putting this great meeting together and for the opportunity to share some of our work. Maria Rohm Helmholtz Munich | @HelmholtzMunich

nature.com/articles/s4225…

✨Congratulations to Mauricio Berriel Diaz, Maria Rohm, and Stephan Herzig on their new #review article in Nature Metabolism, which provides a comprehensive overview of the pathomechanisms contributing to #cancer-induced #wastingsyndrome.👏 🔗rdcu.be/d07O1

Cancer Cachexia: Liver Identified as Active Driver of Body Wasting 👉 t1p.de/eh136 Up to half of all #cancer patients experience #cachexia – a severe syndrome marked by dramatic loss of muscle, fat, and even heart tissue. It is a major cause of therapy resistance,

Delighted to share our newest story study on cancer cachexia. Many thanks to all authors.

A REV-ERBα mechanism by which the liver contributes to peripheral tissue wasting in #cancer cachexia, offering perspectives for future therapeutic interventions cell.com/cell/fulltext/…?

Now online! Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia dlvr.it/TM3YgJ