Bert van de Kooij
@bertkooij
Strong interest in how signalling pathways regulate cell behaviour, and become deregulated in cancer cells. Development of molecular tools to study signalling.
ID: 1164788539206225920
23-08-2019 06:36:58
23 Tweet
69 Followers
67 Following
1/2 Our new paper is out today in nature showing that 53BP1 and RIF1 form an autonomous functional module that stabilises 3D chromatin topology at sites of DNA damage. Read about it here: nature.com/articles/s4158ā¦ University of Copenhagen Novo Nordisk Foundation @NNFCPR Gopal Karemore
New study by Raghu Chivukula (Raghu Chivukula, MD PhD š«) & colleagues identifies inactivating mutations in protein kinase NEK10 cause a new genetic human lung disease through widespread effects on the ciliary proteome go.nature.com/2GjAUrC #genetics
Please share in your biochemist-network: we have a postdoc position available to identify novel small molecule inhibitors to kill BRCA-deficient tumours. Exciting stuff to do! In collaboration with Haico van Attikum @haicovanattikum.bsky.social. lumc.nl/over-het-lumc/ā¦
Our collaborative paper with Michael Yaffe lab is online, revealing crosstalk between end-joining, single-strand annealing and homologous recombination using new multi-pathway DNA double-strand break repair reporters. Great work by Bert van de Kooij and Alex Kruswick! biorxiv.org/content/10.110ā¦
Glad to share out latest work on new DNA double strand break reporters (DSB-Spectrum) done together with the Haico van Attikum @haicovanattikum.bsky.social lab, that demonstrate cross-talk between HR, NHEJ and SSA. Great job Bert van de Kooij and Alex Kruswick! biorxiv.org/cgi/content/shā¦
Excited that the review I wrote with Haico van Attikum @haicovanattikum.bsky.social on fluorescent DSB-repair reporters is out in Frontiers - Genetics! We describe the traditional reporters, but also the most recently developed Cas9-based systems that simultaneously detect multiple pathways. doi.org/10.3389/fgene.ā¦
Our new paper in Nature Communications: crosstalk between end-joining, single-strand annealing and homologous recombination using new multi-pathway DNA double-strand break repair reporters. Great work by Bert van de Kooij and Alex Kruswick, in collaboration with Michael Yaffe nature.com/articles/s4146ā¦
Happy to share our collaborative work with Sylvie Noordermeer lab showing that BRCA1-deficient cells depend on EXO1-mediated repair by SSA. Fantastic work by Bert van de Kooij, Anne Schreuder and Raphael Pavani with great help from andre nussenzweig lab and Edwin Cuppen labs! biorxiv.org/content/10.110ā¦
New pre-print from the lab! Fanconi anemia proteins not only repair DNA interstrand crosslinks, but also DNA double-strand breaks. Great work by Bert van de Kooij, Fenna van der Wal, in collaboration with @marcelvanvugt, altmeyerlab and YaffeLab! biorxiv.org/content/10.110ā¦
Our new paper in Nature Communications shows that Fanconi anemia proteins promote end resection to repair double-strand breaks by homologous recombination. Great work by Bert van de Kooij, Fenna van der Wal, with @marcelvanvugt , altmeyerlab and YaffeLab! nature.com/articles/s4146ā¦