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I am extremely happy to share our latest research done by Gilbert Ansa on characterising how SF3B1 inhibition affects multiple P-TEFb recruitment pathways to chromatin, explaining part, but not all, of the transcriptional changes after SF3B1 inhibition! biorxiv.org/content/10.110…

🇬🇧Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells. ImPact team Pierre Cordelier article from CRCT-Oncopole published in Communications Biology ➡️crct-inserm.fr/en/targeting-t…

❗❗📚💡 Targeting cancer with small-molecule pan-KRAS degraders from Boehringer Ingelheim and Alessio Ciulli lab science.org/doi/10.1126/sc…

There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :) bioicons.com/pdb2vector/

It is out! #NanoPlex is the universal strategy for multiplexing any immunofluorescence using erasable #nanobodies from NanoTag. We showcase easy multiplexed STED, STORM, and 21-plex Confocal #Microscopy. Published in Nature Communications here: rdcu.be/dWvzO

📚💡 ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect academic.oup.com/database/artic… #TPD #Targeted_Protein_Degradation

Happy to share "Protocol to identify E3 ligases amenable to biodegraders using a cell-based assay" STAR Protocols sciencedirect.com/science/articl… It refers to our previous article doi.org/10.1016/j.isci… Thanks Marie Sorbara Margot Cristol Anaïs Cornebois Pierre Cordelier CRCT-Oncopole

Free scientific illustrations for biologists! 😍 NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov

📣 We are hiring! Interested in KRAS inhibition and resistance in lung cancer? We are looking for a POSTDOC for an AECC-funded project. The position will be available for 3 years, incorporation in January 2025. For more information see: cicancer.org/professional-c…

Looking forward to speaking Cell Symposia #CSChembio2024 organized in San Francisco next week! I will talk about "Targeting hard-to-drug proteins in cancer with potent intracellular biodegraders", including the work of Marie Sorbara in the lab of Pierre Cordelier CRCT-Oncopole

Very glad to have presented my PhD work and to have heard such inspiring talks at Cell Symposia focused on drugging the undrugged in San Francisco 🌉 A big thanks to my supervisors for giving me this opportunity Nicolas Bery Pierre Cordelier CRCT-Oncopole #CSChembio2024

It was a great pleasure to present Cell Symposia #CSchembio2024 our work on intracellular biodegraders in beautiful San Francisco!!

Today I had the honour giving a seminar Sarafan ChEM-H Stanford University hosted by Prof. Laura Dassama. It was a wonderful experience with scientific discussions, visit of the campus and a great dinner!! Thanks to Laura and her lab members for their kindness! That was a great week!

Save the date! On March 25th, We'll dive into Nanofluidic tools for studying DNA repair with Fredrik Westerlund @FWesterlundand and R-loops & genome instability with Sidrit Uruci Sidrit Uruci (Sid) & Agnese Cristini Agnese Cristini.

Check out this #protocol by Mathéa Geraud Agnese Cristini Lara Fernandez andrea carla ajello Favre/Sordet team et al for single-cell analysis of DNA double-strand break production and repair in cell-cycle phases by automated high-content microscopy: star-protocols.cell.com/protocols/4059. 🔬🧬Research in

Always great to hear the original RAScal Channing Der Der Lab at UNC talk about KRAS & KRAS inhibitors. Thanks to Channing and his team for putting together such great overview slides. As of March 2025, there are 45 inhibitors (!) & 160 clinical trials. Absolutely amazing. David S. Hong MD

Quelle ambiance au Parc des Princes qui reprend l'hymne du PSG ! 🎵

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction | Science science.org/doi/10.1126/sc…

A beautiful and important Cancer Discovery study by Sandra Misale dissecting the distinct oncogenic signaling of RAS G12 and Q61 mutations and how they impact responses to therapy. aacrjournals.org/cancerdiscover…