Another great example that mouse hematopoiesis does not necessarily reflect the situation in humans: FLT3L regulates #monocyte (&DC and B cell) development in humans. Congrats Vivien Béziat & Co: dlvr.it/T6LHDc

What does FLT3L do in humans? Here’s the answer(s)!! Stunning work by Mana Casanova Lab Vivien Béziat. Thrilled to be part of this phenomenal work w Guerin Antoine ErikaDellaMina Cindy Ma Garvan Institute of Medical Research.

Congratulation to @beziatv et al. for a tour de force study showing that Flt3L deficiency strongly affects adult hematopoietic progenitors, B cells, monocytes and DC development while macrophages remained intact in humans. cell.com/cell/fulltext/…

Scientists describe 3 patients with FMS-related tyrosine kinase 3 ligand (FLT3L) deficiency. Interestingly, FLT3L deficiency impairs monocytes in humans but not mice, and impairs NK cells in mice but not in humans. Vivien Béziat Casanova Lab Mana ow.ly/6O3l50RzW00

We report deleterious UNC93B1 variants as the cause of lupus in ~8% of kindreds in the @crow_lab cohort. These variants elevate TLR7 and/or TLR8 responses, driving elevated IFN and inflammatory cytokine production.

1/ Excited to share our latest publication in PNASNews! We report two patients with autosomal recessive RelB deficiency. Check out the thread for key highlights from our study! 🧵👇doi.org/10.1073/pnas.2…

1/ Excited to report in Journal of Experimental Medicine more about the causes and consequences of human autoantibodies neutralizing type I IFNs through the study of a rare disease: shorturl.at/cWcCa

1/ Thrilled to share our latest publication in @JCI on humans with inherited IL7 deficiency! 🧵👇 jci.org/articles/view/…

1/ I am thrilled to share my main PhD project, conducted at Casanova Lab under the supervision of Anne Puel, just published in @JCI, on autosomal recessive IL-7 deficiency in humans! 🧵👇jci.org/articles/view/…

1/ I am excited to share our new paper from Casanova Lab published today in Journal of Experimental Medicine about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem.20…).

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what-happ… article here: nature.com/articles/s4158… O'Jay Stewart BogunovicLab and a huge international team thank you 🙏🏼 Columbia Children's Health Lipschultz Precision Immunology Institute

Materna, Vivien Béziat et al. @institutimagine report children with complete TCRα deficiency, a lack of αβ T cells, & a severe condition. Previously characterized TCRα deficiency, which wasn't as severe as expected, was partial, as opposed to complete hubs.la/Q03qMb0m0